- Method for synthesizing 2-aminobenzophenone compound
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The invention discloses a method for synthesizing a 2-aminobenzophenone compound, and belongs to the technical field of organic synthesis. According to the key point of the technical scheme, the method comprises the following steps that an N-nitroso-2-ami
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Paragraph 0074-0076
(2019/02/04)
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- Synthesis of 2-aminobenzophenones through acylation of anilines with α-oxocarboxylic acids assisted by: Tert -butyl nitrite
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In this paper, a regioselective, efficient and convenient synthesis of 2-aminobenzophenones through acylation of anilines with α-oxocarboxylic acids assisted by tert-butyl nitrite is presented. Interestingly, tert-butyl nitrite acts as not only an efficient and mild nitrosation reagent, but also a sustainable oxidant required in the Pd(ii)-catalyzed decarboxylative acylation. Meanwhile, the NO unit turned out to be an easily introduced and readily removable directing group for the regioselective acylation.
- Wang, Qianqian,Zhang, Xinying,Fan, Xuesen
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p. 7737 - 7747
(2018/11/02)
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- Enantioselective Intramolecular Copper-Catalyzed Borylacylation
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An enantioselective copper-catalyzed intramolecular borylacylation is reported. The reaction proceeds through an initial enantioselective borylcupration of the styrene, followed by a nucleophilic attack on the tethered carbamoyl chloride. The products, chiral borylated 3,3-disubstituted oxindoles, were generated in excellent yields and enantioselectivities. The versatile carbon–boron bond provides a platform for a wide array of diversification.
- Whyte, Andrew,Burton, Katherine I.,Zhang, Jingli,Lautens, Mark
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supporting information
p. 13927 - 13930
(2018/10/02)
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- Palladium-catalyzed oxidative C-H bond acylation of N-nitrosoanilines with toluene derivatives: A traceless approach to synthesize N-alkyl-2-aminobenzophenones
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A palladium-catalyzed cascade cross-coupling of N-nitroso-anilines and toluene derivatives for the direct synthesis of N-alkyl-2-aminobenzophenones is described. N-nitroso groups in anilines can act as the traceless directing groups while toluene derivatives can serve as effective acyl precursors under mild reaction conditions.
- Wu, Yinuo,Feng, Ling-Jun,Lu, Xiao,Kwong, Fuk Yee,Luo, Hai-Bin
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supporting information
p. 15352 - 15354
(2015/01/08)
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- Silica gel-mediated hydroamination/semipinacol rearrangement of 2-alkylaminophenylprop-1-yn-3-ols: Synthesis of 2-oxindoles from alkynes and 1-(2-aminophenyl) ketones
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2-Alkylaminophenylprop-1-yn-3-ols, prepared from the lithium diisopropylamide (LDA)- mediated 1,2-addition of alkynes to 1-(2-aminophenyl) ketones, can be converted to 3,3-disubstituted 2-oxindoles by using silica gel in n-hexane/ ethyl acetate (20:1 v/v) as the reaction medium. The utility of the approach as a potential scale-up strategy for the synthesis of 2-oxindoles was exemplified by the large-scale synthesis of one adduct in excellent yield. The synthetic applicability of this chemistry was also demonstrated by the recycling of the silica gel up to 8 times with no apparent loss of activity being observed for the same example.
- Susanti, Dewi,Ng, Linda Li Ru,Chan, Philip Wai Hong
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supporting information
p. 353 - 358
(2014/05/20)
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- Bakers' yeast-catalyzed reductive cleavage of 3-aryl-2,1-benzisoxazoles and its quaternary salts: An efficient green synthesis of 2-aminobenzophenones
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3-Aryl-2,1-benzisoxazoles and its salts underwent reductive cleavage of the N-O bond leading to 2-aminobenzophenones with bakers' yeast under non-fermenting conditions in aqueous media. The procedure gives excellent yields of 2-alkylamino- and 2-aminobenzophenones.
- Lekhok, Kushal C.,Prajapati, Dipak,Boruah, Ramesh C.,Mazumder, Sharbani,Borah, Tarun C.
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experimental part
p. 1183 - 1187
(2011/10/01)
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- A convenient method for the production of ortho-amino and N-alkylaminobenzophenones
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ortho-Amino and N-alkylaminobenzophenones 3 have been prepared in good yields by the reductive cleavage of 2,1-benzisoxazole and its salts with Zn-AlCl3*6H2O/THF system.
- Dutta, Dilip Kumar,Konwar, Dilip
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p. 690 - 691
(2007/10/02)
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- A Convenient Preparation of Alkylaminobenzophenones from 2,1-Benzisoxazolium Salts and Iodotrimethylsilane
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2-Alkylaminobenzophenones (2) have been prepared in good yields from 2,1-benzisoxazolium salts (1) and iodotrimethylsilane.
- Konwar, D.,Boruah, R. C.,Sandhu, J. S.
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p. 975 - 976
(2007/10/02)
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