39573-20-1

Basic information

• Product Name: (5-BROMO-2-METHYLAMINO-PHENYL)-PHENYL-METHANONE
• Synonyms: (5-BROMO-2-METHYLAMINO-PHENYL)-PHENYL-METHANONE
• CAS NO: 39573-20-1
• Molecular Formula: C₁₄H₁₂BrNO
• Molecular Weight: 290.17
• Mol File: 39573-20-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 97 °C
• Boiling Point: 438.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.428±0.06 g/cm3(Predicted)
• PKA: 2.12±0.12(Predicted)
• CAS DataBase Reference: (5-BROMO-2-METHYLAMINO-PHENYL)-PHENYL-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (5-BROMO-2-METHYLAMINO-PHENYL)-PHENYL-METHANONE(39573-20-1)
• EPA Substance Registry System: (5-BROMO-2-METHYLAMINO-PHENYL)-PHENYL-METHANONE(39573-20-1)

Safety Data

• Hazardous Substances Data: 39573-20-1(Hazardous Substances Data)

Usage

General Description

(5-BROMO-2-METHYLAMINO-PHENYL)-PHENYL-METHANONE is a chemical compound with a molecular formula C13H11BrNO. It is a ketone derivative with a phenyl group and a bromo-substituted 2-methylamino-phenyl group. (5-BROMO-2-METHYLAMINO-PHENYL)-PHENYL-METHANONE is widely used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical ingredients. It has also been studied for its potential biological activities, including its role in cancer treatment and as an anti-inflammatory agent. Additionally, it is used as a reagent in organic synthesis and has potential applications in medicinal chemistry and drug discovery research.

Upstream product

• 39859-36-4 2-amino-5-bromobenzophenone 
• 77-78-1 dimethyl sulfate 
• 6911-87-1 4-bromo-N-methylaniline 
• 611-73-4 Benzoylformic acid 
• 106874-91-3 5-bromo-2-(methylamino)benzonitrile 
• 100-58-3 phenylmagnesium bromide 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 108-88-3 toluene 
• 937-23-5 4-bromo-N-nitroso-N-methylaniline 
• 74-88-4 methyl iodide 
• 94579-32-5 2-N-Tosylamino-5-bromobenzophenone 
• 63335-21-7 C₁₄H₁₁BrNO⁽¹⁺⁾*CH₃O₄S^(1-) 
• 94863-99-7 N-(2-benzoyl-4-bromophenyl)-N,4-dimethylbenzenesulfonamide 
• 16029-98-4 trimethylsilyl iodide 

Downstream Products

• 1610460-74-6 3-benzyl-5-bromo-1-methyl-3-phenylindolin-2-one 
• 63563-58-6 8-bromo-1-methyl-6-phenyl-3,4-dihydro-1H-benzo[1,5]diazocin-2-one 
• 104542-58-7 2-methyl(N-carbobenzoxy-α-alanyl-glycyl)amido-5-bromobenzophenone 

Relevant articles and documents

Method for synthesizing 2-aminobenzophenone compound

The invention discloses a method for synthesizing a 2-aminobenzophenone compound, and belongs to the technical field of organic synthesis. According to the key point of the technical scheme, the method comprises the following steps that an N-nitroso-2-ami

Enantioselective Intramolecular Copper-Catalyzed Borylacylation

An enantioselective copper-catalyzed intramolecular borylacylation is reported. The reaction proceeds through an initial enantioselective borylcupration of the styrene, followed by a nucleophilic attack on the tethered carbamoyl chloride. The products, chiral borylated 3,3-disubstituted oxindoles, were generated in excellent yields and enantioselectivities. The versatile carbon–boron bond provides a platform for a wide array of diversification.

Silica gel-mediated hydroamination/semipinacol rearrangement of 2-alkylaminophenylprop-1-yn-3-ols: Synthesis of 2-oxindoles from alkynes and 1-(2-aminophenyl) ketones

2-Alkylaminophenylprop-1-yn-3-ols, prepared from the lithium diisopropylamide (LDA)- mediated 1,2-addition of alkynes to 1-(2-aminophenyl) ketones, can be converted to 3,3-disubstituted 2-oxindoles by using silica gel in n-hexane/ ethyl acetate (20:1 v/v) as the reaction medium. The utility of the approach as a potential scale-up strategy for the synthesis of 2-oxindoles was exemplified by the large-scale synthesis of one adduct in excellent yield. The synthetic applicability of this chemistry was also demonstrated by the recycling of the silica gel up to 8 times with no apparent loss of activity being observed for the same example.