- Levodopa methyl ester hydrochloride synthetic method
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The invention relates to a synthesis method of L-dopa methyl ester hydrochloride, which comprises the following steps: by using veratone as a raw material, carrying out amidation to obtain 2-amino-3-(3,4-dimethoxyphenyl)propanamide, carrying out amide oxidation into carboxy group to obtain 2-amino-3-(3,4-dimethoxyphenyl)propionic acid, removing methoxy group to obtain 2-amino-3-(3,4-dihydroxyphenyl)propionic acid, and finally, carrying out methyl ester conversion and acidification to obtain the target product 2-amino-3-(3,4-dimethoxyphenyl)alanine methyl ester hydrochloric acid. The method has the advantages of accessible reaction raw materials, ingenious technique concept, simple steps and no use of virulent reagents, is simple to operate, conforms to the requirements for green chemical industry, and is suitable for industrial production.
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- Synthesis of the Chromophore of Pseudobactin, a Fluorescent Siderophore from Pseudomonas
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Protected forms of dihydroxyphenylalanine (DOPA) were converted to the corresponding dihydroquinolin-2-ones 13 by nitration and reductive cyclization.Subsequent N-alkylation with α-halo-γ-aminobutyric acid derivatives provided the carbon framework 12 for the chromophore of pseudobactin.Conversion to protected forms of the fluorescent chromophore 5 was accomplished by reaction of 12 with Lawesson's reagent to produce the corresponding thioamide which was cyclized by reaction with mercuric acetate.
- Kolasa, Teodozyj,Miller, Marvin J.
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p. 4246 - 4255
(2007/10/02)
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