40611-00-5

Basic information

• Product Name: Tyrosine, 3-hydroxy-,methyl ester, hydrochloride (1:1)
• Synonyms: Tyrosine, 3-hydroxy-,methyl ester, hydrochloride (1:1);3-hydroxy- Tyrosine methyl ester, hydrochloride (1:1);2-Amino-3-(3,4-dihydroxy-phenyl)-propionic acid methyl ester
• CAS NO: 40611-00-5
• Molecular Formula: C₁₀H₁₃NO₄*ClH
• Molecular Weight: 247.67546
• Mol File: 40611-00-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 384.4°Cat760mmHg
• Flash Point: 186.3°C
• Appearance: /
• Density: 1.322g/cm³
• CAS DataBase Reference: Tyrosine, 3-hydroxy-,methyl ester, hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Tyrosine, 3-hydroxy-,methyl ester, hydrochloride (1:1)(40611-00-5)
• EPA Substance Registry System: Tyrosine, 3-hydroxy-,methyl ester, hydrochloride (1:1)(40611-00-5)

Safety Data

• Hazardous Substances Data: 40611-00-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 38, p. 3057, 1973 DOI: 10.1021/jo00957a034

Upstream product

• 776-99-8 3,4-dimethoxyphenylacetone 
• 67-56-1 methanol 
• 63-84-3 dopa 

Downstream Products

• 128217-72-1 3-(3,4-Bis-benzyloxy-phenyl)-2-(2,5-dioxo-pyrrolidin-1-yl)-propionic acid methyl ester 
• 128217-69-6 N-[2-(3,4-Bis-benzyloxy-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid methyl ester 
• 102750-27-6 3,4-diacetoxy-N-(N,N-phthaloyl-glycyl)-DL-phenylalanine-methyl ester 
• 90924-67-7 DL-dopachrome methyl ester 
• 81143-33-1 3,4-Dihydroxyphenyl-N-alanin-methylester 
• 93023-12-2 N,O,O-Triacetyl-DL-dopamethylester 
• 81477-98-7 methyl N-(diphenylmethylene)-DL-3-hydroxytyrosinate 
• 102003-45-2 3,4-dihydroxy-N-(N,N-phthaloyl-glycyl)-DL-phenylalanine-methyl ester 
• 128217-78-7 N-[2-(4,5-Bis-benzyloxy-2-nitro-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid methyl ester 
• 128217-82-3 3-(4,5-Bis-benzyloxy-2-nitro-phenyl)-2-(2,5-dioxo-pyrrolidin-1-yl)-propionic acid methyl ester 
• 106787-68-2 3-(3,4-Diacetoxy-phenyl)-2-thioacetylamino-propionic acid methyl ester 
• 106787-69-3 N-methylthiocarbonyl-3,4-dihydroxyphenylalanine methyl ester 
• 106807-01-6 methyl cis-6,7-dihydro-1-(2-phenyl)ethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride 
• 106807-02-7 methyl cis-6,7-dihydro-1-(2-phenyl)ethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrobromide 

Relevant articles and documents

Levodopa methyl ester hydrochloride synthetic method

The invention relates to a synthesis method of L-dopa methyl ester hydrochloride, which comprises the following steps: by using veratone as a raw material, carrying out amidation to obtain 2-amino-3-(3,4-dimethoxyphenyl)propanamide, carrying out amide oxidation into carboxy group to obtain 2-amino-3-(3,4-dimethoxyphenyl)propionic acid, removing methoxy group to obtain 2-amino-3-(3,4-dihydroxyphenyl)propionic acid, and finally, carrying out methyl ester conversion and acidification to obtain the target product 2-amino-3-(3,4-dimethoxyphenyl)alanine methyl ester hydrochloric acid. The method has the advantages of accessible reaction raw materials, ingenious technique concept, simple steps and no use of virulent reagents, is simple to operate, conforms to the requirements for green chemical industry, and is suitable for industrial production.

Sulphydryl compounds in melanogenesis. Part II. Reactions of cysteine and glutathione with dopachrome

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New compounds: synthesis of alkyl esters of D,L-dopa.

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