- Bivalent palladium complexes, conjugated aromatic compound and conjugated aromatic hydrocarbon polymer
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The invention provides a bivalent palladium complex having a structure in a formula (I), a formula (II) or a formula (III) and a preparation method of the bivalent palladium complex. The invention also provides a conjugate aromatic hydrocarbon compound ha
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Paragraph 0209; 0210; 0215; 0221; 0226; 0231; 0236
(2018/02/04)
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- COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS
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The invention provides compounds of formulae (I) and (II) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRcalpha PDGFRbeta) kinases
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Page/Page column 125; 126
(2013/03/28)
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- Synthesis, characterization, in vitro cytotoxicity and anti-inflammatory activity of palladium(II) complexes with tertiary phosphines and heterocyclic thiolates: Crystal structure of [PdC28H19N8PS2]
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The new four-coordinated mononuclear palladium(II) complexes 1-9 with chelating heterocyclic thiolates and tertiary phosphines with general formula [Pd(L)nCl(R′R2P)] (L = Pym2SH (pyrimidine-2-thiolate), Pur6SH (purine-6-thiolate), Py2SH (pyridine-2-thiolate), R3P = PPh3, P(o-tolyl)3, PPh2Cl), n = 1, 2) have been synthesized by the direct reaction of [PdCl2(R′R2P)2] with polyfunctional heterocyclic thiolates which display a wide variety of coordinations. These compounds were characterized by elemental analysis, FT-IR and multinuclear (1H, 13C and 31P) NMR. The X-ray diffraction study of non-ionic compound 5 showed that the thiolate acts as unidentate and that the chelating (-N,S) ligand adopts a slightly distorted square planar geometry around the palladium atom. In vitro the anti-inflammatory inhibition of compounds 1-9 was 10-15% greater than that of the standard drug Declofenac. Compounds 1 and 4 showed mostly a moderate to low cytotoxicity against seven human tumor cell lines whereas compound 3 was somewhat more active.
- Shaheen, Farkhanda,Badshah, Amin,Gielen, Marcel,Gieck, Christine,Jamil, Mariyam,de Vos, Dick
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p. 1117 - 1126
(2008/04/13)
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- Palladium-catalyzed Suzuki-Miyaura cross-coupling of various aryl halides using ortho-alkyl-substituted arylphosphanes and (ortho-alkylphenyl)- alkylphosphanes under microwave heating
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Mono- and dinuclear palladium(II) chloride complexes of various ortho-alkyl-substituted aryl- and alkylphosphanes were prepared. Subsequently, these were characterized by 1H NMR and 31P{1H} NMR spectroscopy, X-ray crystallographic studies and mass spectroscopy. The palladium complexes were screened as potential catalysts for the microwave-assisted Suzuki-Miyaura coupling reaction of several aryl halides under aerobic conditions. A preliminary study showed that excellent results can be obtained even for electron-rich bromides and unactivated aryl chlorides with an optimized solvent, base and catalyst loading using specific phosphane ligands. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
- Vuoti, Sauli,Autio, Juho,Laitila, Minna,Haukka, Matti,Pursiainen, Jouni
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p. 397 - 407
(2008/09/17)
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- Special effects of ortho-isopropylphenyl groups. Diastereoisomerism in platinum(II) and palladium(II) complexes of helically chiral PAr3 ligands
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The coordination chemistry of the four phosphines, P{C6H 3(o-CH3)(p-Z)}3 where Z = H (1a) or OMe (1b) and P{C6H3(o-CHMe2)(p-Z)}3 Z = H (1c) or OMe (1d) with platinum(II) and palladium(II) is reported. Mononuclear complexes trans-[PdCl2L2] (L = 1a,b) and trans-[PtCl 2L2] (L = 1a-c) have been prepared and the crystal structures of trans-[PdCl2(1b)2] and trans-[PtCl 2(1c)2] as their dichloromethane solvates have been determined. The structures show that in these complexes, the ligands adopt g+g+a conformations. Examination of the Cambridge Structural Database confirms this to be one of only two conformer types that tri-o-tolylphosphines adopt and the only viable conformer in 4 and 6 coordinate complexes. The binuclear complexes trans-[Pd2Cl4L 2] (L = 1c,d) are formed even when an excess of the bulky 1c,d is used in the synthesis and the crystal structure of trans-[Pd2Cl 4(1c)2] as its chloroform solvate is reported. Reaction of [PtCl2(NCBu1)2] with 1b-d in refluxing toluene gave the cycloplatinated species [Pt2Cl2(L - H) 2] where L - H is phosphine 1b-d deprotonated at one of the ortho-methyl carbon atoms. Variable temperature 31P and 1H NMR spectroscopy reveals that all the complexes reported are fluxional. The processes are analysed in terms of restricted P-C and P-M rotations that give rise to diastereoisomeric rotamers because of the helically chiral orientations of the aryl substituants. For the complexes of the bulky ligands 1c,d, rotation about the P-C bond is slow on the NMR timescale even up to 75°C. The crystal structure of the cyclometallated complex [Pt2Cl2(1d - H)2] has been determined. The Royal Society of Chemistry 2005.
- Baber, R. Angharad,Orpen, A. Guy,Pringle, Paul G.,Wilkinson, Matthew J.,Wingad, Richard L.
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p. 659 - 667
(2007/10/03)
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