- Substituted Carbazoles-A New Class of Anthelmintic Agent
-
A series of novel carbazoles were synthesized based on structural modifications to lead carbazole 1 (EC100≤2.5M against Haemonchus contortus in vitro), which was revealed in a small molecule screening program as a potentially promising platform for the development of new anthelmintic drugs. Subsequently, analogues 19, 21, 41, 42 (EC100≤ 1.25M, all), and 39 (EC100≤0.625M) were demonstrated to exhibit enhanced in vitro anthelmintic activity over the lead structure, with compound 39 also being shown to be active in vivo against Heligmosomoides polygyrus.
- Rennison, David,Gueret, Stephanie M.,Laita, Olivia,Bland, Ross J.,Sutherland, Ian A.,Boddy, Ian K.,Brimble, Margaret A.
-
p. 1268 - 1276
(2016/11/25)
-
- HEPATITIS C VIRUS ENTRY INHIBITORS
-
The present invention relates to the use of tricyclic diphenylamine derivative compounds for prevention and/or treatment of Hepatitis C virus (HCV) infection by inhibiting HCV entry into permissive cells.
- -
-
Page/Page column 57
(2010/11/30)
-
- Carbazole neuropeptide Y5 antagonists
-
Carbazoles of the formula which are effective in treating conditions associated with neuropeptide Y-5 neurotransmission.
- -
-
-