432506-50-8Relevant articles and documents
Substituted Carbazoles-A New Class of Anthelmintic Agent
Rennison, David,Gueret, Stephanie M.,Laita, Olivia,Bland, Ross J.,Sutherland, Ian A.,Boddy, Ian K.,Brimble, Margaret A.
, p. 1268 - 1276 (2016/11/25)
A series of novel carbazoles were synthesized based on structural modifications to lead carbazole 1 (EC100≤2.5M against Haemonchus contortus in vitro), which was revealed in a small molecule screening program as a potentially promising platform for the development of new anthelmintic drugs. Subsequently, analogues 19, 21, 41, 42 (EC100≤ 1.25M, all), and 39 (EC100≤0.625M) were demonstrated to exhibit enhanced in vitro anthelmintic activity over the lead structure, with compound 39 also being shown to be active in vivo against Heligmosomoides polygyrus.
Carbazole neuropeptide Y5 antagonists
-
, (2008/06/13)
Carbazoles of the formula which are effective in treating conditions associated with neuropeptide Y-5 neurotransmission.