- Reactions of thiyl radicals with phenothiazines and other antioxidants in aqueous solutions. A pulse radiolysis study.
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Reaction rate constants of thiyl radicals with phenothiazines, promethazine (PMZ), chlorpromazine (CPZ), prochlorperazine (PPZ), trimeperazine tarterate (TPZ), and other antioxidants, e. g., ascorbic acid and 2,2-azinobis(3-ethyl benzthiazoline-6 sulphonate) (ABTS) have been estimated using pulse radiolysis technique.In general they are quite high (108-109 M-1 s-1).The k value of cysteine, cysteamine, mercaptoethanol, and mercaptopropionic acid with similar structures and molecular weights are more or less similar for PMZ, CPZ, and PPZ.Rate constants are lower in value for PenS., DT.T, DT.E and GuS. radicals of phenothiazines showing that they are dependent upon the structure and the molecular weight of the compound. Rate constants are the same whether the thiyl radicals are generated from thiols or their corresponding disulphides.The k values for chlorine-containing phenothiazines, chlorpromazine, and prochlorperazine are higher than those of promothazine.
- Lal, Manohar,Mahal, H. S.
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p. 1376 - 1382
(2007/10/02)
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