- Processes for the Synthesis of Levocetirizine and Intermediates for Use Therein
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The present invention provides a compound of formula (IV) wherein R is Cl, Br, NO2, OH or OR′, and R′ is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (?)-1-[(4-chlorophenyl)-phenylmethyl]piperazin
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Page/Page column 8
(2011/08/06)
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- METHOD FOR PREPARING (R)-(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE
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The present invention relates to a novel method for preparing (R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine of formula (I), which is useful as an intermediate for preparing an antihistamine, levocetirizine.
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Page/Page column 7
(2009/07/18)
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- PROCESSES FOR THE SYNTHESIS OF LEVOCETIRIZINE AND INTERMEDIATES FOR USE THEREIN
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The present invention provides a compound of formula (IV) wherein R is Cl, Br, NO2, OH or OR', and R' is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (-)-1-[(4-chlorophenyl)-phenyl methyl] piperaz
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- Asymmetric synthesis of cetirizine dihydrochloride
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Practical route technology for the preparation of (S)-cetirizine·2HCl via diastereoselective organometallic addition to N-tert-butanesulfinyl aldimines is disclosed.
- Pflum, Derek A,Krishnamurthy, Dhileepkumar,Han, Zhengxu,Wald, Stephen A,Senanayake, Chris H
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p. 923 - 926
(2007/10/03)
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