439858-21-6

Basic information

• Product Name: (S)-(+)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
• Synonyms: (S)-(+)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
• CAS NO: 439858-21-6
• Molecular Formula: C₁₇H₁₉ClN₂
• Molecular Weight: 286.81
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 439858-21-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 409.1°C at 760 mmHg
• Flash Point: 193.3°C
• Appearance: /
• Density: 1.158g/cm³
• Vapor Pressure: 6.66E-07mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.99±0.10(Predicted)
• CAS DataBase Reference: (S)-(+)-1-[(4-Chlorophenyl)phenylmethyl]piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-1-[(4-Chlorophenyl)phenylmethyl]piperazine(439858-21-6)
• EPA Substance Registry System: (S)-(+)-1-[(4-Chlorophenyl)phenylmethyl]piperazine(439858-21-6)

Safety Data

• Hazardous Substances Data: 439858-21-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Intermediate in the production of (S)-Cetirizine (C281105).

InChI:InChI=1/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2/t17-/m0/s1

Upstream product

• 1198162-47-8 (-)-1-[(4-chloro-phenyl)-phenyl-methyl]-4-(4-methoxy-benzyl)piperazine oxalate 
• 1198162-49-0 C₂H₂O₄*C₁₇H₁₉ClN₂ 
• 1198162-46-7 (-)-1-[(4-chloro-phenyl)-phenyl-methyl]-4-(4-methoxy-benzyl)piperazine 
• 2018-61-3 (S)-2-acetylamino-3-phenylpropanoic acid 
• 303-26-4 N-(4-chlorobenzhydryl)piperazine 
• 439695-63-3 (R_S,S)-(1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropanesulfinamide 
• 336105-23-8 (R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide 
• 163837-32-9 (S)-4-chloro-α-phenyl-benzenemethanamine 
• 186249-76-3 (R,E)-2-methyl-N-(phenylmethylene)-2-propanesulfinamide 
• 100-52-7 benzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 163837-58-9 1-[(S)-(4-Chloro-phenyl)-phenyl-methyl]-4-(toluene-4-sulfonyl)-piperazine 

Downstream Products

• 1198162-49-0 C₂H₂O₄*C₁₇H₁₉ClN₂ 
• 1252612-74-0 2-{4-[(S)-(4-chlorophenyl)(phenyl)methyl]-1-piperazinyl}-1-(4-{[(3-nitrophenyl)methylidene]amino}phenyl)ethanone 
• 1252612-73-9 2-{4-[(S)-(4-chlorophenyl)(phenyl)methyl]-1-piperazinyl}-1-(4-{[(4-methylphenyl)methylidene]amino}phenyl)ethanone 
• 1252612-72-8 2-{4-[(S)-(4-chlorophenyl)(phenyl)methyl]-1-piperazinyl}-1-(4-{[(4-methoxyphenyl)methylidene]amino}phenyl)ethanone 
• 1252612-71-7 2-{4-[(S)-(4-chlorophenyl)(phenyl)methyl]-1-piperazinyl}-1-(4-{[(2-methoxyphenyl)methylidene]amino}phenyl)ethanone 

Relevant articles and documents

Processes for the Synthesis of Levocetirizine and Intermediates for Use Therein

The present invention provides a compound of formula (IV) wherein R is Cl, Br, NO2, OH or OR′, and R′ is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (?)-1-[(4-chlorophenyl)-phenylmethyl]piperazin

METHOD FOR PREPARING (R)-(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE

The present invention relates to a novel method for preparing (R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine of formula (I), which is useful as an intermediate for preparing an antihistamine, levocetirizine.