- Electrochemical two-electron oxygen reduction reaction (ORR) induced aerobic oxidation of α-diazoesters
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Electrochemical oxygen reduction reaction (ORR) is a powerful tool for introducing oxygen functional groups in synthetic chemistry. However, compared with the well-developed one-electron oxygen reduction process, the applications of two-electron oxygen re
- Chen, Liang,Gao, Meng,Lu, Cuifen,Ma, Chao,Ruan, Mengyao,Wen, Ziyang,Yang, Fan,Yang, Guichun
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p. 2168 - 2171
(2022/02/17)
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- Selective Transformation of Vicinal Glycols to α-Hydroxy Acetates in Water via a Dehydrogenation and Oxidization Relay Process by a Self-Supported Single-Site Iridium Catalyst
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α-Hydroxy acids have attracted broad attention because of their prevalence in bioactive molecules and biodegradable polymers, but their conventional syntheses are usually restricted to aromatic substrates, especially, in a stepwise manner. Herein, we disclose the transformation of alkyl and aryl vicinal glycols to α-hydroxy acetates in water under the air atmosphere with our solid self-supported NHC-Ir single-site catalyst. Both aliphatic and aromatic glycols are compatible with a much higher catalytic efficiency in the presence of this solid single-site catalyst than other viable molecular catalysts (93% vs a dehydrogenation facilitated by the catalyst, and then it proceeds through an unexpected oxidization relay step by oxygen in the air, leading to the α-hydroxy acetate formation. Our protocol can potentially contribute to the valorization of readily available and inexpensive diols.
- Shen, Lingyun,Chen, Zhe-Ning,Zheng, Qingshu,Wu, Jiajie,Xu, Xin,Tu, Tao
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p. 12833 - 12839
(2021/10/29)
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- Cobalt-Catalyzed Transfer Hydrogenation of α-Ketoesters and N-Cyclicsulfonylimides Using H2O as Hydrogen Source
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A Co-catalyzed effective transfer hydrogenation of various α-ketoesters and N-cyclicsulfonylimides by safe and environmentally benign H2O as hydrogen source is described. The reaction used easily available and easy to handle zinc metal as a reductant. Interestingly, the catalytic system does not require ligand for reduction of N-cyclicsulfonylimides. (Figure presented.).
- Gao, Yang,Zhang, Xuexin,Laishram, Ronibala Devi,Chen, Jingchao,Li, Kangkui,Zhang, Keyang,Zeng, Guangzhi,Fan, Baomin
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supporting information
p. 3991 - 3997
(2019/08/02)
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- Method for selectively catalytically synthesizing mandelate ester compound from metallocene complex
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The invention discloses a method for selectively catalytically synthesizing a mandelate ester compound from a metallocene complex. According to the method, a perfluoroalkane (aromatic) metallocene complex is used as a catalyst; mandelic acid, derivatives thereof and alcohol are used as main raw materials, wherein benzyl hydroxyls in mandelic acid and a derivative II thereof do not have esterification reaction with carboxy groups of mandelic acid but carboxy groups of mandelic acid and the derivative II thereof have esterification reaction with carboxy groups of alcohol III; the materials highly selectively react in the presence of an organic solvent or without a solvent, so that the mandelate ester compound in higher yield can be acquired. The method has the advantages of lower cost, high yield, simple and convenient operation and no pollution and has potential industrial application prospect. The method can be a low-cost and green method for preparing the mandelate ester compound.
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Paragraph 0021; 0022; 0068; 0069
(2017/09/26)
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- Pharmaceutical composition and process of treatment
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A process for alleviating proliferative skin diseases such as psoriasis, atopic dermatitis, etc. comprising administering to humans, or domesticated animals, topically and/or systemically a composition comprising a pharmaceutical carrier and at least one active compound selected from the groups, substituted alkyl zanthines, tricyclic antidepressants, organic nitrates, antihypertensives, anti-asthma agents and central nervous system depressants and combinations of certain compounds from specifically named groups of compounds.
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