- Synthesis method of benzocaprolactam
-
The invention discloses a synthesis method of benzocaprolactam. The synthesis method comprises the following steps: S1, using o-nitrotoluene as a raw material, and carrying out a condensation reactionon the o-nitrotoluene and an acrylate under catalysis o
- -
-
Paragraph 0028; 0034-0035
(2019/11/28)
-
- Novel, Cyclically Substituted Furopyrimidine Derivatives and Use Thereof
-
The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
- -
-
Page/Page column 24
(2011/06/19)
-
- Histone deacetylase inhibitors
-
This invention relates to novel Histone deacetylases inhibitors. Also disclosed is a method for treating mucositis or cancer with these inhibitors.
- -
-
Page/Page column 8
(2011/12/03)
-
- GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO
-
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure, wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
- -
-
Page/Page column 76; 77
(2008/12/04)
-
- Carboxylic acid derivatives, process for producing the same and drugs containing the same as the active ingredient
-
A carboxylic acid derivative of formula (1) wherein R1 is COOH, COOR6 etc.; A is alkylene etc.; R2 is alkyl, alkenyl, alkynyl etc.; B is carbocyclic ring or heterocyclic ring; R4 is alkyl, cycloalkyl etc.; Rsup
- -
-
-
- 1-Aryl-3-(2-chloroethyl) ureas: Synthesis and in vitro assay as potential anticancer agents
-
1-Aryl-3-(2-chlorethyl) ureas and 1-aryl-3-nitrose-3-(2-chloroethyl) ureas, derived from 4-phenylbutyric acid and alkylanillines, were synthesized and their cytotoxicity was evaluated on human adenocarcinoma cells in vitro. Methyl 4-[p-[3-(2-chloroethyl)ureido]-phenyl]butyrate, 4-methyl [3-(2-chloroethyl)ureido]benzene, and 4-butyl[3-(2-chloroethyl)ureido]benzene were found to be at least as cytotoxic as 4-[p-[bis-(2-chloroethyl)amino]phenyl]butyric acid (chlorambucil), while their N-nitrose derivatives were inactive.
- Gaudreault,lacroix,Page,Joly
-
p. 185 - 187
(2007/10/02)
-