- Deconstructive di-functionalization of unstrained, benzo cyclic amines by C-N bond cleavage using a recyclable tungsten catalyst
-
With H2WO4 as the catalyst and H2O2 as the oxidant, we herein report a deconstructive difunctionalization of the C-N bond in unstrained, benzo cyclic amines to generate an ester group and nitro group simultaneously. The preliminary mechanistic studies suggested that the corresponding hydroxamic acid is the key intermediate for this transformation. Importantly, with the utilization of this transformation, we achieved an interesting approach for the ring contraction of quinoline to indole, an example of scaffold hopping in a hetero-aromatic system.
- Zhang, Yujing,Sun, Shuai,Su, Yijin,Zhao, Jian,Li, Yong-Hong,Han, Bo,Shi, Feng
-
supporting information
p. 4970 - 4974
(2019/05/29)
-
- Synthesis method of benzocaprolactam
-
The invention discloses a synthesis method of benzocaprolactam. The synthesis method comprises the following steps: S1, using o-nitrotoluene as a raw material, and carrying out a condensation reactionon the o-nitrotoluene and an acrylate under catalysis o
- -
-
Paragraph 0028; 0033; 0036-0038
(2019/11/28)
-
- Histone deacetylase inhibitors
-
This invention relates to novel Histone deacetylases inhibitors. Also disclosed is a method for treating mucositis or cancer with these inhibitors.
- -
-
Page/Page column 8
(2011/12/03)
-
- Novel, Cyclically Substituted Furopyrimidine Derivatives and Use Thereof
-
The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
- -
-
Page/Page column 24
(2011/06/19)
-
- Carboxylic acid derivatives, process for producing the same and drugs containing the same as the active ingredient
-
A carboxylic acid derivative of formula (1) wherein R1 is COOH, COOR6 etc.; A is alkylene etc.; R2 is alkyl, alkenyl, alkynyl etc.; B is carbocyclic ring or heterocyclic ring; R4 is alkyl, cycloalkyl etc.; Rsup
- -
-
-
- Process for preparation of 1,5-diaminonaphthalenes
-
In a process where an ortho-alkylnitrobenzene derivative and a vinyl compound as starting materials are used to prepare a 1,5-diaminonaphthalene derivative via a 4-(2-nitrobenzene)propane derivative and a 5-nitro-1-tetralone derivative, the ortho-alkylnit
- -
-
-
- 1-Aryl-3-(2-chloroethyl) ureas: Synthesis and in vitro assay as potential anticancer agents
-
1-Aryl-3-(2-chlorethyl) ureas and 1-aryl-3-nitrose-3-(2-chloroethyl) ureas, derived from 4-phenylbutyric acid and alkylanillines, were synthesized and their cytotoxicity was evaluated on human adenocarcinoma cells in vitro. Methyl 4-[p-[3-(2-chloroethyl)ureido]-phenyl]butyrate, 4-methyl [3-(2-chloroethyl)ureido]benzene, and 4-butyl[3-(2-chloroethyl)ureido]benzene were found to be at least as cytotoxic as 4-[p-[bis-(2-chloroethyl)amino]phenyl]butyric acid (chlorambucil), while their N-nitrose derivatives were inactive.
- Gaudreault,lacroix,Page,Joly
-
p. 185 - 187
(2007/10/02)
-