- Synthesis of mono- and bis-substituted anthraquinones as inhibitors of human telomerase
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A number of anthraquinone derivatives have been synthesized in good yield and tested for their ability to inhibit the enzymes telomerase and Taq polymerase using a modified telomeric repeat amplification protocol. In addition, all the synthesized compounds were screened against a panel of ovarian carcinoma cell lines (A2780, CH1 and SKOV-3) to determine their cytotoxicity. All compounds tested inhibited telomerase at a concentration of 10 μM, but showed negligible inhibition of Taq polymerase. None of the compounds tested displayed significant general cell toxicity in ovarian cancer cell lines. The synthesized compounds are potential selective inhibitors of human telomerase.
- Gibson,Anderson,Jenkins,Cairns
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- Preparation process for dihydroxyl anthraquinone leuco body
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The invention discloses a synthesis method for a dihydroxyl anthraquinone leuco body. The synthesis method is characterized in that under nitrogen-gas atmosphere, 1,4-dihydroxyl anthraquinone, boric acid and methanol are sequentially added into a high-pressure reaction kettle; hydrogen gas is led in after stirring and heating; cooling is performed after reaction is ended, suction filtration is performed, a filter cake is washed with water, and drying is performed to obtain a target product dihydroxyl anthraquinone leuco body. The preparation process adopts a solvent process, is less in three wastes (waste water, waste gas and waste solid), generates a byproduct, namely water, and is clean and environmentally friendly.
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Paragraph 0015-0020
(2018/09/13)
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- Near-IR region absorbing 1,4-diaminoanthracene-9,10-dione motif?based?ratiometric chemosensors for Cu2+
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1,4-Bis[2-aminoethylamino]anthracene-9,10-diones selectively bind with Cu2+ to form complexes with unusual selectivity under basic conditions. The deprotonation of the aryl amine NH in the case of these chemosensors causes a bathochromic shift in the absorption band from 585 nm and 635 nm to 725 nm and enables ratiometric estimation of Cu2+ between pH 8 and 12.
- Kaur, Navneet,Kumar, Subodh
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p. 3168 - 3175
(2008/09/19)
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- Anthraquinone-oligodeoxynucleotide conjugates as triple helix stabilizing agents
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A number of anthraquinones have been synthesized and linked to a 10-mer homopyrimidine oligodeoxynucleotide. All the anthraquinone-oligodeoxynucleotide conjugates exhibited sequence specific triple helix formation when tested by DNase I footprinting. Neither the presence of an ionizable side chain nor the position of substitution of the anthraquinone appeared to affect triplex stability.
- Gibson,Anderson,Brown,Hartley,Cassidy,Fox,Cairns
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- Thermodynamics of semiquinone disproportionation in aqueous buffer
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The thermodynamic parameters, Kdisp, ΔH° and ΔS°, controlling the disproportionation of semiquinones derived from 1,4-benzoquinone (BQ), 1,4-naphthoquinone (NQ), 2-methylbenzoquinone (MBQ), menadione (MNQ), naphthazarin (NZQ) and quinizarin (QNZ), have been determined. Smaller disproportionation constants, Kdisp, are observed upon addition of a fused benzene ring to the semiquinone structure. Negative enthalpies and positive entropies of disproportionation govern the disproportionation equilibria. Addition of OH groups to the 5 and 8 positions in NQ?- displaces the disproportionation equilibrium to the semiquinone probably due to intramolecular hydrogen bonding.
- Alegria, Antonio E.,Lopez, Marcos,Guevara, Norberto
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p. 4965 - 4968
(2007/10/03)
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