- INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF
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The present application relates to compounds of Formula I (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.
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- On the origins of diastereoselectivity in the alkylation of diketopiperazine enolates
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High levels of diastereoselectivity are observed for benzylation of the lithium enolates of (S)-N,N′-bis-para-methoxybenzyl-3-iso-propyl- piperazine-2,5-dione, (S)-N(1)-para-methoxybenzyl-N(4)-methyl-3-iso-propyl- piperazine-2,5-dione and (S)-N(1)-methyl-
- Bull, Steven D.,Davies, Stephen G.,Garner, A. Christopher,Parkes, Alastair L.,Roberts, Paul M.,Sellers, Thomas G. R.,Smith, Andrew D.,Tamayo, Juan A.,Thomson, James E.,Vickers, Richard J.
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p. 486 - 495
(2008/01/27)
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- Influence of N(2)-substitution in the alkylation of (4S)-alkyl-2,4-dihydro- 1H-pyrazino[2,1-b]quinazoline-3,6-diones
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1-Alkylation of O(3)-lactim, N(11)-azaenolate dilithium species derived from N(2)-H compounds 1a and 1b and the lithium azaenolates derived from the N(2)-phenyl and N(2)-(1-arylethyl) substituted compounds 2, 3 and 4 is studied. In 1 the trans-diastereose
- Hernandez, Fernando,Morales, Viviana,Buenadicha, Felix L.,Soellhuber, Monica,Avendano, Carmen
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p. 3045 - 3058
(2007/10/03)
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- Homochiral supramolecular polymerization of an "S"-shaped chiral monomer: Translation of optical purity into molecular weight distribution
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An "S"-shaped chiral motif of a p-xylylene-bridged bis(cyclic dipeptide) (1), having four hydrogen-bonding amide functionalities, formed a homochiral supramolecular polymer in solution. X-ray crystallography of a slightly modified version of 1 for an enha
- Ishida, Yasuhiro,Aida, Takuzo
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p. 14017 - 14019
(2007/10/03)
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