Diastereoselective synthesis of quaternary α-amino acids from diketopiperazine templates
Sequential enolate alkylations of (S)-N(1)-methyl-5-methoxy-6-isopropyl-3, 6-dihydropyrazin-2-one and (S)-N(1)-p-methoxybenzyl-5-methoxy-6-isopropyl-3,6- dihydropyrazin-2-one proceed with excellent levels of diastereoselectivity (>90% de) affording quaternary α-amino acids in high enantiomeric excess (>98% ee) after deprotection and hydrolysis. This journal is The Royal Society of Chemistry.
Davies, Stephen G.,Christopher Garner,Ouzman, Jaqueline V. A.,Roberts, Paul M.,Smith, Andrew D.,Snow, Emma J.,Thomson, James E.,Tamayo, Juan A.,Vickers, Richard J.
p. 2138 - 2147
(2008/03/14)
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