Compounds inhibiting the aggregation of superoxide dismutase-1
The invention is directed to methods of inhibiting the rate at which superoxide dismutse-1 (SOD) aggregates using compounds that stabilize SOD dimers. The methods are useful in the study and therapy of amyotrophic lateral sclerosis. The invention also includes assays that can be used to identify compounds that stabilize dimers and SOD molecules that have been modified for use in these assays.
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Page/Page column 22; sheet 14
(2008/06/13)
Improved nucleic acid triggered probe activation through the use of a 5-thiomethyluracil peptide nucleic acid building block
(Chemical Equation Presented) To improve the efficiency of a nucleic acid triggered probe activation (NATPA) system a 5-thiomethyluracil peptide nucleic acid (PNA) building block has been synthesized. Attachment of imidazole and a coumarin ester to uracils at the ends of two PNAs resulted in a 550 000-fold acceleration of DNA-triggered coumarin release relative to imidazole and a 6-fold increase in kcat relative to a system which had these groups attached to the amino and carboxy ends of PNAs.
Cai, Jianfeng,Li, Xiaoxu,Taylor, John Stephen
p. 751 - 754
(2007/10/03)
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