4874-36-6 Usage
General Description
5-Mercaptomethyluracil, also known as thiomersal, is a chemical compound with the formula C5H6N2O2S. It is a derivative of uracil and contains a thiol group, which gives it the ability to act as a reducing agent and form covalent bonds with metal ions. Thiomersal is commonly used as a preservative in vaccines and other medical products to prevent bacterial and fungal contamination. It has also been used as a topical antiseptic and as a treatment for various skin conditions. However, concerns have been raised about its potential toxicity and its use in vaccines has become controversial, leading to its removal from many vaccine formulations. Overall, thiomersal is a versatile chemical with various applications, but its safety and efficacy continue to be the subject of debate.
Check Digit Verification of cas no
The CAS Registry Mumber 4874-36-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,7 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4874-36:
(6*4)+(5*8)+(4*7)+(3*4)+(2*3)+(1*6)=116
116 % 10 = 6
So 4874-36-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H6N2O2S/c8-4-3(2-10)1-6-5(9)7-4/h1,10H,2H2,(H2,6,7,8,9)
4874-36-6Relevant articles and documents
Gupta et al.
, p. 973,975 (1975)
Improved nucleic acid triggered probe activation through the use of a 5-thiomethyluracil peptide nucleic acid building block
Cai, Jianfeng,Li, Xiaoxu,Taylor, John Stephen
, p. 751 - 754 (2007/10/03)
(Chemical Equation Presented) To improve the efficiency of a nucleic acid triggered probe activation (NATPA) system a 5-thiomethyluracil peptide nucleic acid (PNA) building block has been synthesized. Attachment of imidazole and a coumarin ester to uracils at the ends of two PNAs resulted in a 550 000-fold acceleration of DNA-triggered coumarin release relative to imidazole and a 6-fold increase in kcat relative to a system which had these groups attached to the amino and carboxy ends of PNAs.
