Detoxification system for inorganic arsenic: Transformation of As 2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine
A new two-step synthetic pathway developed for the transformation of arsenic trioxide [iAs(iii); As2O3] into arsenobetaine (AB; Me3As+CH2CO2-) involves treatment of iAs(iii) with native B12 or biomimetic B12 in the presence of glutathione (GSH) to give TMAO with a high selectivity and a high conversion rate; subsequent treatment of TMAO with iodoacetic acid in the presence of GSH gives arsenobetaine. The Royal Society of Chemistry.
COMPOSITION FOR ALKYLATION, AND METHOD FOR DETOXIFICATION OF TOXIC COMPOUND USING THE COMPOSITION
It is an object of the present invention to provide a beneficial composition in order to detoxify the harmful compound containing arsenic etc. effectively and systematically and a method for detoxifying a harmful compound by using the composition. The composition for the alkylation according to the present invention is characterized in that the composition contains a cobalt complex. The method of detoxifying the harmful compound according to the present invention is characterized in that a harmful compound containing at least one element selected from the groups comprising arsenic, antimony and selenium is detoxified by the alkylation of the harmful compound, in the presence of the composition according to the present invention.
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(2009/06/27)
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