4964-14-1

Basic information

• Product Name: TRIMETHYLARSINE OXIDE
• Synonyms: TRIMETHYLARSINE OXIDE;trimethyl-arsineoxid;dimethylarsorylmethane;Trimethylarsinoxide;Arsine oxide, trimethyl-
• CAS NO: 4964-14-1
• Molecular Formula: C₃H₉AsO
• Molecular Weight: 136.02
• Mol File: 4964-14-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 170.7 °C at 760 mmHg
• Flash Point: 56.4 °C
• Appearance: /
• Vapor Pressure: 1.93mmHg at 25°C
• CAS DataBase Reference: TRIMETHYLARSINE OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIMETHYLARSINE OXIDE(4964-14-1)
• EPA Substance Registry System: TRIMETHYLARSINE OXIDE(4964-14-1)

Safety Data

• Hazardous Substances Data: 4964-14-1(Hazardous Substances Data)

Usage

Uses

Trimethylarsinoxide is an organic derivative of arsine and is an building block to other organoarsenic compounds.

InChI:InChI=1/C3H9AsO/c1-4(2,3)5/h1-3H3

Synthetic route

sodium (methyl)(aquo)cobyrinate perchlorate → trimethylarsine oxide (4964-14-1)

Conditions	Yield
With GLUTATHIONE; arsenic(III) trioxide at 100℃; for 2h; pH=8; aq. buffer;	99%

methylcobalamin + arsenic(III) trioxide → trimethylarsine oxide (4964-14-1)

Conditions	Yield
With GLUTATHIONE In water at 100℃; for 2h; pH=8; Product distribution / selectivity; Tris-HCl buffer solution;	97%

methylcobalamine → trimethylarsine oxide (4964-14-1)

Conditions	Yield
With GLUTATHIONE; arsenic(III) trioxide at 100℃; for 2h; pH=8; aq. buffer;	97%

methylcobalamin + arsenic(III) trioxide → monomethylarsinic acid + cacodyloxide (418758-51-7) + trimethylarsine oxide (4964-14-1)

Conditions	Yield
With GLUTATHIONE In water at 100℃; for 2h; pH=8; Product distribution / selectivity; Tris-HCl buffer solution;	A 6% B 14% C 79%
With GLUTATHIONE In water at 100℃; for 2h; pH=8; Product distribution / selectivity; Tris-HCl buffer solution;	A 41% B 30% C 15%

trimethylarsine (593-88-4) → trimethylarsine oxide (4964-14-1)

Conditions	Yield
With sulfuric acid at 150 - 250℃;
With oxygen
With diethyl ether; bromine Behandlung des Reaktionsprodukts mit wss.K2CO3-Loesung;

trimethylarsine (593-88-4) → trimethylarsine oxide (4964-14-1) + Dimethylarsinic acid (75-60-5)

Conditions	Yield
With air
With diethyl ether

bis-{dimethylarsenic}-oxide (503-80-0) → trimethylarsine oxide (4964-14-1)

Conditions	Yield
With water; oxygen

bis-{dimethylarsenic}-oxide (503-80-0) + methyl iodide (74-88-4) → trimethylarsine oxide (4964-14-1)

Conditions	Yield
With methanol; sodium hydroxide

trimethylarsine (593-88-4) + sulfuric acid (7664-93-9) → trimethylarsine oxide (4964-14-1)

Conditions	Yield
at 250℃;

trimethylarsine (593-88-4) + oxygen → trimethylarsine oxide (4964-14-1)

methanol (67-56-1) + bis-{dimethylarsenic}-oxide (503-80-0) + methyl iodide (74-88-4) + sodium hydroxide → trimethylarsine oxide (4964-14-1)

trimethylarsine (593-88-4) + air → trimethylarsine oxide (4964-14-1) + Dimethylarsinic acid (75-60-5)

(4-carboxy-phenyl)-trimethyl-arsonium betaine + alcoholic KOH-solution → trimethylarsine oxide (4964-14-1) + benzoic acid (65-85-0)

methylcobalamin + Dimethylarsinic acid (75-60-5) → trimethylarsine oxide (4964-14-1)

Conditions	Yield
With GLUTATHIONE In water at 37℃; for 22h; pH=7.6; Product distribution / selectivity; Tris-HCl buffer solution;

trimethylarsine oxide (4964-14-1) + Iodoacetic acid (64-69-7) → arsenobetaine (64436-13-1)

Conditions	Yield
With GLUTATHIONE at 37℃; for 2h; aq. buffer;	99%
With methylcobalamin; GLUTATHIONE In water at 37℃; for 94h; pH=7.6; Product distribution / selectivity; Tris-HCl buffer solution;

tin(IV) fluoride bis(acetonitrile) (148556-51-8, 125940-11-6, 7590-35-4) + trimethylarsine oxide (4964-14-1) → [SnF4((CH3)3AsO)2] (883143-74-6, 882872-02-8)

Conditions	Yield
In dichloromethane all manipulations under N2 atm.; Sn compd. suspended in CH2Cl2, ligand added, stirred for 2 h at room temp.; filtered, recrystd. from hot CH2Cl2, dried in vac.; elem. anal.;	92%

antimony(V) chloride (7647-18-9) + trimethylarsine oxide (4964-14-1) → SbCl5(OAs(CH3)3) (37979-82-1)

Conditions	Yield
In tetrachloromethane; dichloromethane under N2; soln. of ligand (sublimed in vac. before use) in CH2Cl2 added to stirred soln. of SbCl5 (molar ratio 1:1) in CCl4; concd. in vac.; filtered; ppt. dried; elem. anal.;	80%

scandium(III) chloride hexahydrate + trimethylarsine oxide (4964-14-1) → Sc[(CH3)3AsO]6(3+)*3Cl(1-)=Sc[(CH3)3AsO]6Cl3

Conditions	Yield
In ethanol mixed in boiling ethanol; concd., filtered, dried.(vac.), elem. anal.;	71%

scandium bromide hexahydrate + trimethylarsine oxide (4964-14-1) → Sc[(CH3)3AsO]6(3+)*3Br(1-)=Sc[(CH3)3AsO]6Br3

Conditions	Yield
In ethanol mixed in boiling ethanol; concd., filtered, dried.(vac.), elem. anal.;	62%

lanthanum(III) nitrate hexahydrate + trimethylarsine oxide (4964-14-1) → La((CH3)3AsO)6(3+)*3NO3(1-)=[La((CH3)3AsO)6](NO3)3

Conditions	Yield
In acetone boiling solns. of La(NO3)3*6H2O in acetone added to soln. of Me3AsO; refrigerated overnight; solid filtered off; dried in vac.; elem. anal.;	55%

trimethylarsine oxide (4964-14-1) + scandium iodide heptahydrate + water (7732-18-5) → Sc[(CH3)3AsO]6(3+)*3I(1-)*3H2O=Sc[(CH3)3AsO]6I3*3H2O

Conditions	Yield
In ethanol mixed in warm (60°C) ethanol, stirred for 1 h; filtered, dried.(vac.), elem. anal.;	53%

yttrium(lll) nitrate hexahydrate + trimethylarsine oxide (4964-14-1) + water (7732-18-5) → Y((CH3)3AsO)6(3+)*3NO3(1-)*H2O=[Y((CH3)3AsO)6](NO3)3*H2O

Conditions	Yield
In ethanol solns. of Y(NO3)3*6H2O and Me3AsO in ice-cold ethanol mixted; stirred for 1 h; soln. conctd. in vac. to 10 cm**3 and refrigerated overnight; solid filtered off; dried in vac.; elem. anal.;	53%

yttrium(III) chloride hexahydrate + trimethylarsine oxide (4964-14-1) → Y(OAs(CH3)3)6(3+)*3Cl(1-)=[Y(OAs(CH3)3)6]Cl3

Conditions	Yield
In ethanol compd. dissolved in boiling ethanol, a soln. of ligand added; solvent removed (vac.), ppt. dissolved (acetone), standed; elem. anal.;	43%

scandium(III) nitrate hydrate + trimethylarsine oxide (4964-14-1) → Sc((CH3)3AsO)6(3+)*3NO3(1-)=[Sc((CH3)3AsO)6](NO3)3

Conditions	Yield
In ethanol solns. of Sc(NO3)3*5H2O and Me3AsO in ice-cold ethanol mixted; stirred for 1 h; soln. conctd. in vac. to 10 cm**3 and refrigerated overnight; solid filtered off; dried in vac.; elem. anal.;	38%

lanthanum(III) nitrate hexahydrate + trimethylarsine oxide (4964-14-1) → La((CH3)3AsO)2(H2O)(NO3)3 (385825-72-9)

Conditions	Yield
In ethanol boiling soln. of La(NO3)3*6H2O treated with soln. of Me3AsO; refrigerated overnight; solid filtered off; dried in vac.; elem. anal.;	20%

trimethylarsine oxide (4964-14-1) + mercury dichloride → trimethylhydroxidearsonium trichloromercurate(II)

Conditions	Yield
In water in acidic aq. soln.;

(Nb(OCH3)5)2 + trimethylarsine oxide (4964-14-1) → Nb(OCH3)5(CH3)3AsO (36500-14-8)

Conditions	Yield
In acetonitrile equilibrium react.;; detected by PMR-measurements;;
In acetonitrile equilibrium react.;; detected by PMR-measurements;;

trimethylarsine oxide (4964-14-1) + indium(III) chloride (10025-82-8) → (Me3AsO)3(indium trichloride)2 (104002-66-6)

Conditions	Yield
In ethanol ppt. from ethanol or acetone, extn. into boiling acetone;
In acetone mixing acetone solns. of InCl3 (1 mmol) and (CH3)3AsO (2 mmol) under anhydrous conditions; addn. of petroleum ether, pptn.; recrystn. from acetone; elem anal.;

trimethylarsine oxide (4964-14-1) + thorium tetrachloride (10026-08-1) → thorium tetrachloride * 6 trimethylarsine oxide

Conditions	Yield
In acetone anhydrous thorium tetrachloride in ice-cold acetone is added dropwise to an acetone soln. of (CH3)3AsO, stoichiometric quantity of (CH3)3AsO used;
In acetone dry N2-atmosphere; pptn. on dropwise addn. of filtered soln. of metal compd. to stoich. amt. of ligand; filtration, washing (Me2CO), drying (vac.); elem. anal.;

Upstream product

• 503-80-0 bis-{dimethylarsenic}-oxide 
• 74-88-4 methyl iodide 
• 593-88-4 trimethylarsine 
• 75-60-5 Dimethylarsinic acid 
• 67-56-1 methanol 
• 7664-93-9 sulfuric acid 

Downstream Products

• 64436-13-1 arsenobetaine 
• 593-57-7 dimethylarsine 
• 593-88-4 trimethylarsine 
• 593-52-2 methylarsine 

Relevant articles and documents

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COMPOSITION FOR ALKYLATION, AND METHOD FOR DETOXIFICATION OF TOXIC COMPOUND USING THE COMPOSITION

It is an object of the present invention to provide a beneficial composition in order to detoxify the harmful compound containing arsenic etc. effectively and systematically and a method for detoxifying a harmful compound by using the composition. The composition for the alkylation according to the present invention is characterized in that the composition contains a cobalt complex. The method of detoxifying the harmful compound according to the present invention is characterized in that a harmful compound containing at least one element selected from the groups comprising arsenic, antimony and selenium is detoxified by the alkylation of the harmful compound, in the presence of the composition according to the present invention.