- Synthesis and characterisation of some coumarin-1,2,4-triazol-3-thioether hybrid molecules
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A new series of N′-{[(4-methyl/phenyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio]acetyl}-2-oxo-2H-chromene-3-carbohydrazides was synthesised via the reaction of 2-[(4-methyl/phenyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio]acetohydrazides and 3-(1H-benzotriazol-1-ylcarbonyl)-2H-chromen-2-ones in good yields.
- Yilmaz, Fatih,Mente?e, Emre
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- Alkylation of 1,2,4-triazole-3-thiols with haloalkanoic acid esters
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Alkylation of 4,5-disubstituted 4H-1,2,4-triazole-3-thiols with methyl chloroformate and ethyl chloroacetate chemoselectively afforded the corresponding S-alkyl derivatives, whereas the alkylation of 5-benzyl-4-phenyl-4H-1,2,4-triazole-3-thiol with methyl 3-bromopropanoate gave an inseparable mixture of S- and N-alkylation products. Hydrazinolysis of S-(5-benzyl-4-phenyl-4H-1,2,4-triazol-3-yl) methyl carbonothioate involved anomalous cleavage with formation of the initial 4,5-disubstituted 1,2,4-triazole and methyl hydrazinecarboxylate.
- Samvelyan,Ghochikyan,Grigoryan,Tamazyan,Aivazyan
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p. 935 - 940
(2017/08/02)
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- Synthesis and Antimicrobial Evaluation of New Schiff Base Hydrazones Bearing 1,2,4-Triazole Moiety
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This study presents the synthesis and spectral analysis of new Schiff base hydrazone derivatives. New compounds were prepared by the reaction of [(4-phenyl-5-substituted-4H-1,2,4-triazol-3-yl)sulfanyl] acetohydrazide with various aldehydes. The structures
- Popiolek, Lukasz,Kosikowska, Urszula,Wujec, Monika,Malm, Anna
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p. 1611 - 1623
(2015/11/02)
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- Synthesis and antimicrobial evaluation of some novel 1,2,4-triazole and 1,3,4-thiadiazole derivatives
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This study presents the synthesis and spectral analysis of new derivatives of 1,2,4-triazole-3-thione and 1,3,4-thiadiazole. New compounds were prepared by cyclization reaction of acyl thiosemicarbazide derivatives in the presence of alkaline and acidic media. All synthesized compounds were screened for their in vitro antibacterial activity by using the agar dilution technique. Six of the compounds had potential activity against Gram-positive bacteria (minimal inhibitory concentration [MIC] = 15.63-500 μg/mL). Some compounds showed good activity especially against Bacillus subtilis ATCC 6633 (MIC = 15.63-250 μg/mL), Staphylococcus aureus ATCC 25923 (MIC = 31.25-250 μg/mL), and Micrococcus luteus ATCC 10240 (MIC = 125-250 μg/mL).
- Popiolek, Lukasz,Kosikowska, Urszula,Mazur, Liliana,Dobosz, Maria,Malm, Anna
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p. 3134 - 3147
(2013/07/11)
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- Synthesis, in vitro cytotoxicity, and antibacterial studies of new asymmetric bis-1,2,4-triazoles
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A series of asymmetric bis-1,2,4-triazoles (4a-l) were synthesized from respective 1,2,4-triazole-3-thiocarbohydrazides (2a, b) via base catalyzed dehydrative cyclization of thiosemicarbazide intermediates (3a-l). The synthesized compounds were characteri
- Singh, Rohit,Pujar, Gurubasavaraj V.,Purohit, Madhusudan N.,Chandrashekar
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p. 2163 - 2173
(2013/07/26)
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- Syntheses of Substituted 3-Mercapto-1,2,4-triazoles as Potential Antimicrobial Agents
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Some hydrazides (3-5) and amides (6-17) have been prepared by reacting 3,4-disubstituted ethyl 1,2,4-triazole-5-mercaptoacetates (1,2) with hydrazines and alkylamines respectively.Treatment of the hydrazides (3,4) with alkyl or aryl isothiocyanates afford
- Ismaiel, A. M.,Yousif, M. Y.,Metwally, M. A.,El-Kerdawy, M. M.
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p. 489 - 491
(2007/10/02)
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