cas 499195-60-7, ethyl 4-(2-chloropyrimidin-4-yl)benzoate | Articles data ｜lookchem

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499195-60-7

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N-CYANOMETHYLAMIDES AS INHIBITORS OF JANUS KINASE
The present invention relates to compounds of general formula (1) that are inhibitors of Janus Kinase (JAK), a family of tyrosine kinases that are involved in inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant reject
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Page/Page column 17; 18

(2015/02/25)

PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF
The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.
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Page/Page column 56-57

(2008/12/07)

A novel and efficient synthesis of 4-phenyl-2-chloropyrimidines from acetophenone cyanoimines
A versatile and efficient 2 step synthesis of 4-phenyl-2-chloropyrimidines is described. The reaction proceeds by treatment of acetophenone cyanoimines under Vilsmeier-Haack conditions to give the target compounds in moderate yields.
Cuccia, Salvatore J.,Fleming, Linda B.,France, Donald J.,Wood, William W.
p. 3011 - 3018
(2007/10/03)

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Chemical Properties

Melting Point: 120-124 °C
Boiling Point: 442.9±28.0 °C(Predicted)
Density: 1.265±0.06 g/cm3(Predicted)
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
PKA: -1.83±0.20(Predicted)
PSA: 52.08000
LogP: 2.97370

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