- First synthesis of pyrrolo[1,2:1′,2′]azepino[5,6-b]indole derivatives
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A new family of pyrrolo[1,2:1′,2′]azepino[5,6-b]indole derivatives 8,15 related to anthramycin skeleton was prepared in good yield from indole-2-carboxylic acid and β-aminoesters 4 through intramolecular cyclisation.
- Perron, Julien,Joseph, Beno?t,Mérour, Jean-Yves
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- Total synthesis of tetracyclic kynurenic acid analogues isolated from chestnut honey
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A short and efficient synthesis of novel tetracyclic Kynurenic acid analogues, isolated from chestnut honey, is described. The crucial step of the strategy was a MW-assisted cyclization of enamines of ethyl dioxohexahydropyrrolizine and 2,3-dioxooctahydroindolizine carboxylates to obtain 2,3,6,11b-tetrahydro-1H-pyrrolizino[2,1-b]quinoline-5,11-dione and 5,8,91,011,11a-hexahydroindolizino[2,1-b]quinoline-6,12-dione, respectively. Because of its modular nature, the synthetic strategy can have value as a general method for the preparation of compounds containing these new heterocyclic scaffolds.
- Cincinelli, Raffaella,Beretta, Giangiacomo,Dallavalle, Sabrina
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p. 163 - 166
(2017/12/15)
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- Angiotensin II antagonists
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This invention provides novel heterocyclic derivatives, their pharmaceutical formulations, and their use for antagonizing angiotensin II receptors in mammals.
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- Angiotensin II antagonist intermediates
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This invention provides novel heterocyclic derivatives, their pharmaceutical formulations, and their use for antagonizing angiotensin II receptors in mammals.
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- Decarboxylation Reaction. X. Introduction of a Carbon unit at the α-Position of Amines by Reaction of Hexahydro-1,3,5-triazines with Carboxylic Acids
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An efficient method for introducing a carbon unit at the α-position of alicyclic amines is described.The method involves the reaction of monocyclic or tetracyclic hexahydro-1,3,5-triazines with trichloroacetic acid, cyanoacetic acid, malonic acid and their derivatives, which are introduced into the α-position of amines in the decarboxylated form.Keywords --- 1,3,5-trialkylhexahydro-1,3,5-triazine; trimer of alicyclic imine; decarboxylation; β-amino acid; carboxylic acid
- Fukawa, Hidemichi,Terao, Yoshiyasu,Achiwa, Kazuo,Sehiya, Minoru
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- INTRODUCTION OF CARBON UNIT AT THE α-POSITION OF ALICYCLIC AMINES UTILIZING A DECARBOXYLATION REACTION WITH MALONIC ACID DERIVATIVES
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A new method for introducing carbon unit at the α-position of alicyclic amines has been exploited.The method involves a reaction of trimers of alicyclic imines with malonic acid derivatives, of which decarboxylation leads to a formation of carbon-carbon bond at the α-position of alicyclic amines.
- Fukawa, Hidemichi,Terao, Yoshiyasu,Achiwa, Kazuo,Sekiya, Minoru
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p. 231 - 232
(2007/10/02)
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