- B-cholesterol-reducingoxidation derivativeand synthesis method and application thereof
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The invention provides a B-cholesterol-reducingoxidation derivative. The structural formula of the compound is as shown in the description, wherein, R is CH3 or CH3CH2CH2 or CH3CH2CH2CH2. The B-cholesterol-reducingoxidation derivativecompound can significantly inhibit growth and proliferation of tumor cellsof human breast cancer cells, human ductalbreast cancer cells and human ovarian cancer cells,and can be used as drug intermediates or drugs and applied to manufacturing and use of different drugs.
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Paragraph 0033; 0034; 0038
(2019/06/30)
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- Synthesis and characterization of side-chain cholesterol derivatives based on double bond
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After steps of esterification, epoxidation and ring-opening, a series of novel monomers of 5-hydroxyl-6-methacryloyloxy-3-alkylate, CnCOOCh (n = 1, 2, 3, 4, 5) were synthesized. After that, the corresponding polymers (PnCOOCh, n = 1, 2, 3, 4, 5) were obtained by free radical polymerization. The molecular structure, composition and thermal behaviors of monomers and polymers were confirmed by 1H NMR, FTIR, single crystal diffractometer, GPC, DSC and TGA. The results indicate that although their molecular weights are not high, all the polymers have high glass transition (Tg) and degradation temperature. In addition, Tg gradually decreases with increasing of alkyl chain lengths, and the degradation temperature increases with the increase of carbon number.
- Yu, Yun-Long,Bai, Jun-Wei,Zhang, Jun-Hua
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experimental part
p. 1 - 6
(2012/08/08)
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- Cl3CCONH2/PPh3: A versatile reagent for synthesis of esters
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Cl3CCONH2/PPh3 was a versatile reagent to convert carboxylic acids into their corresponding acid chlorides. This intermediate was clearly confirmed by spectroscopic methods (IR, 1H, 13C NMR). This one-pot reaction of in situ acid chloride generated with various alcohols successfully furnished the corresponding esters in moderate to excellent yields. Copyright ? Taylor & Francis Group, LLC.
- Chantarasriwong, Oraphin,Jang, Doo Ok,Chavasiri, Warinthorn
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scheme or table
p. 2845 - 2856
(2009/04/11)
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- Selective Conjugate Reduction of α,β-Unsaturated Esters and Amides via SmI2-Promoted Electron Transfer Process
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α,β-Unsaturated esters and amides were rapidely and selectively reduced to the coresponding saturated ones under mild conditions without affecting coexisting isolated double or triple bonds by using the reduction system, SmI2-N,N-dimethylacetamide (DMA)-proton source.
- Inanaga, Junji,Sakai, Shino,Handa, Yuichi,Yamaguchi, Masaru,Yokoyama, Yasuo
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p. 2117 - 2118
(2007/10/02)
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