- A cyclic dipeptide production method
-
The invention relates to a production method for cyclic dipeptide, and belongs to a natural compound synthesis technology. Cyclic (histidine-proline) dipeptide is prepared by a cooling varying-temperature synthesis and high-pressure high-temperature water phase cyclizing technology. The production method comprises the following steps: taking hydrochloride of histidine proline dipeptide methyl ester as a raw material, and synthesizing high-quality and high-purity cyclic histidine-proline dipeptide by a high-pressure high-temperature assisted method in water containing strong basic and weak acidic salt. Compared with a conventional methanol reflux method, the production method is time-saving, efficient, high in product yield and free of racemization phenomenon.
- -
-
-
- Temperature, pH and H-bond synergism for peptide bond formation: Synthesis of sequence specific tetra- and penta-peptides without using coupling reagent
-
A reaction temperature of 120°C, pH of 5.0 and reaction time of 6 h were chosen as the best conditions for the condensation of two nonactivated amino acids to form a peptide bond. Role of H-bond in these reactions was anticipated. The method was validated
- Singh, Palwinder,Singh, Amrinder,Kaur, Sukhmeet,Mithu, Venus Singh,Bhatti, Manpreet S.
-
p. 37371 - 37374
(2014/12/11)
-
- AGRICULTURAL CHEMICAL CONTAINING 2,5-DIKETOPIPERAZINE DERIVATIVE AS ACTIVE INGREDIENT
-
Disclosed herein is an agricultural agent containing a 2,5-diketopiperazine derivative capable of controlling plant diseases and promoting plant growth or an agriculturally acceptable salt thereof as an active ingredient.
- -
-
Paragraph 0033
(2013/06/05)
-
- Thermodynamic and (1)H NMR Study of Proton Complex Formation of Histidine-containing Cyclodipeptides in Aqueous Solution
-
A thermodynamic and (1)H NMR study of proton complex formation in aqueous solution of some L-histidine-containing cyclic L-dipeptides has been carried out.The enthalpic and entropic changes associated with protonation of the cyclodipeptides, obtained by potentiometric and calorimetric measurements, together with the (1)H NMR data and NOESY experiments, enable the role played by non-covalent interactions in proton complex formation to be assessed.In addition, a comparison with c(Gly-His) permits the influence of side-chain residues on the conformation of protonated species to be observed.
- Arena, Giuseppe,Impellizzeri, Giuseppe,Maccarrone, Giuseppe,Pappalardo, Giuseppe,Sciotto, Domenico,Rizzarelli, Enrico
-
p. 371 - 376
(2007/10/02)
-
- Synthesis, Characterization, and Anorectic Testing of the Four Stereoisomers of Cyclo(histidylproline)
-
All four possible stereoisomers of cyclo(histidylproline) were individually synthesized, purified, and characterized.They were each tested for anoretic activity in rats with a free feeding paradigm over 24 h.Contrary to literature reports, none significantly reduced food intake at any time over the test period.
- Kukla, Michael J.,Breslin, Henry J.,Bowden, Charles R.
-
p. 1745 - 1747
(2007/10/02)
-