53109-32-3

Basic information

• Product Name: CYCLO(-HIS-PRO)
• Synonyms: HIS-PRO, CYCLIC;CYCLO(-HIS-PRO);(3S,6S)-3-(3H-imidazol-4-ylmethyl)-1,4-diazabicyclo[4.4.0]decane-2,5-dione;Histidylproline diketopiperazine;histidylproline dioxopiperazine;Cyclo-Pro-His-HO
• CAS NO: 53109-32-3
• Molecular Formula: C11H14N4O2
• Molecular Weight: 234.25
• Mol File: 53109-32-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 162-164 °C
• Boiling Point: 650.3°Cat760mmHg
• Flash Point: 347.1°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 2.69E-23mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 12.73±0.40(Predicted)
• CAS DataBase Reference: CYCLO(-HIS-PRO)(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLO(-HIS-PRO)(53109-32-3)
• EPA Substance Registry System: CYCLO(-HIS-PRO)(53109-32-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 53109-32-3(Hazardous Substances Data)

Usage

Uses

Cyclo(L-histidyl-L-proline) is used in the pharmaceutical composition comprising cyclo(His-Pro) for preventing or treating obesity.

InChI:InChI=1/C11H16N4O3.C4H6N2O2/c12-8(4-7-5-13-6-14-7)10(16)15-3-1-2-9(15)11(17)18;7-3-4(8)6-2-1-5-3/h5-6,8-9H,1-4,12H2,(H,13,14)(H,17,18);1-2H2,(H,5,7)(H,6,8)

Upstream product

• 97997-80-3 N-(tert-butoxycarbonyl)-L-prolyl-L-histidine methyl ester bis(trifluoroacetate) 
• 147-85-3 L-proline 
• 20866-46-0 N,1'-bis[(1,1-dimethylethoxy)carbonyl]-L-histidine 
• 71-00-1 L-histidine 
• 645-35-2 L-histidine monohydrochloride 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 25582-49-4 Benzyloxycarbonyl-Pro-His-OMe 
• 3304-59-4 N-benzyloxycarbonyl-L-proline p-nitrophenyl ester 
• 66024-30-4 Pro-His-OMe 

Relevant articles and documents

A cyclic dipeptide production method

The invention relates to a production method for cyclic dipeptide, and belongs to a natural compound synthesis technology. Cyclic (histidine-proline) dipeptide is prepared by a cooling varying-temperature synthesis and high-pressure high-temperature water phase cyclizing technology. The production method comprises the following steps: taking hydrochloride of histidine proline dipeptide methyl ester as a raw material, and synthesizing high-quality and high-purity cyclic histidine-proline dipeptide by a high-pressure high-temperature assisted method in water containing strong basic and weak acidic salt. Compared with a conventional methanol reflux method, the production method is time-saving, efficient, high in product yield and free of racemization phenomenon.

AGRICULTURAL CHEMICAL CONTAINING 2,5-DIKETOPIPERAZINE DERIVATIVE AS ACTIVE INGREDIENT

Disclosed herein is an agricultural agent containing a 2,5-diketopiperazine derivative capable of controlling plant diseases and promoting plant growth or an agriculturally acceptable salt thereof as an active ingredient.

Synthesis, Characterization, and Anorectic Testing of the Four Stereoisomers of Cyclo(histidylproline)

All four possible stereoisomers of cyclo(histidylproline) were individually synthesized, purified, and characterized.They were each tested for anoretic activity in rats with a free feeding paradigm over 24 h.Contrary to literature reports, none significantly reduced food intake at any time over the test period.