Synthesis of primary amides by aminocarbonylation of aryl/hetero halides using non-gaseous NH3 and CO sources
Abstract A practically simple method for the synthesis of primary amides via the palladium-catalysed aminocarbonylation of aromatic halides by using solid sources of gaseous ammonia and carbon monoxide is described. The system tolerated a wide variety of hindered and functionalized aryl/hetero halides and afforded good to excellent yields (69-94%) of the amide. Pharmacologically active Exalamide and Pyrazinecarboxamide were synthesised in high yields to demonstrate the effectiveness of this method.
Suresh,Baburajan, Poongavanam,Ahmed, Mansur
supporting information
p. 4864 - 4867
(2015/07/28)
Palladium-catalyzed approach to primary amides using nongaseous precursors
A simple protocol is reported for the preparation of primary aryl amides under Pd-catalyzed carbonylation chemistry applying a two-chamber system with crystalline and nontransition metal based sources of carbon monoxide and ammonia. The method is suitable for the synthesis of a number of primary amides with good functional group tolerance. Incorporation of 13CO into the primary amide group was also found to be effective making this approach useful for accessing carbon isotope labeled derivatives.
Nielsen, Dennis U.,Taaning, Rolf H.,Lindhardt, Anders T.,Gogsig, Thomas M.,Skrydstrup, Troels
supporting information; experimental part
p. 4454 - 4457
(2011/10/05)
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