53370-90-4 Usage
Chemical Properties
White Solid
Originator
Hyperan,S.S. Pharm,Japan,1980
Uses
Exalamide is used as an antifungal (topical). Exalamide is a derivative of salicylamide.
Definition
ChEBI: An arenecarboxamide that is salicylamide in which the phenolic hydroxy group has been converted to the corresponding hexyl ether. It has been used as a topical antifungal agent.
Manufacturing Process
4.6 g sodium were dissolved in 150 ml ethanol and 27.4 g (0.2 mol)
salicylamide added. The solution was refluxed gently and 24.6 g (0.2mol) nhexyl-
bromide added gradually. The mixture was refluxed for six hours, the
precipitated sodium bromide filtered off, and most of the alcohol removed by
distillation. Water was then added to the residue, and the 2-nhexyloxybenzamide
filtered off. It crystallized from 50% aqueous ethanol in
colorless crystals, MP 71°C.
Therapeutic Function
Antifungal
Check Digit Verification of cas no
The CAS Registry Mumber 53370-90-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,3,7 and 0 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 53370-90:
(7*5)+(6*3)+(5*3)+(4*7)+(3*0)+(2*9)+(1*0)=114
114 % 10 = 4
So 53370-90-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H19NO2/c1-2-3-4-7-10-16-12-9-6-5-8-11(12)13(14)15/h5-6,8-9H,2-4,7,10H2,1H3,(H2,14,15)
53370-90-4Relevant articles and documents
Synthesis of primary amides by aminocarbonylation of aryl/hetero halides using non-gaseous NH3 and CO sources
Suresh,Baburajan, Poongavanam,Ahmed, Mansur
supporting information, p. 4864 - 4867 (2015/07/28)
Abstract A practically simple method for the synthesis of primary amides via the palladium-catalysed aminocarbonylation of aromatic halides by using solid sources of gaseous ammonia and carbon monoxide is described. The system tolerated a wide variety of hindered and functionalized aryl/hetero halides and afforded good to excellent yields (69-94%) of the amide. Pharmacologically active Exalamide and Pyrazinecarboxamide were synthesised in high yields to demonstrate the effectiveness of this method.
