- γ-METHYL-γ,δ-EPOXY-α,β-UNSATURATED ALDEHYDE COMPOUND AND FLAVOR COMPOSITION CONTAINING THAT COMPOUND
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PROBLEM TO BE SOLVED: To provide a new compound useful as a flavor ingredient or the like, and a flavor composition containing the compound. SOLUTION: The invention provides: a γ-methyl-γ,δ-epoxy-α,β-unsaturated aldehyde compound represented by the general formula (1) in the figure useful as a flavor ingredient and the like; and a flavor composition containing the compound. (In the formula, the solid line, the double line, H, C, O, R1 and R2 are as defined in the specification.) SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
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Paragraph 0025-0028
(2021/05/21)
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- Efficient macrocyclization by means of 2-nitrobenzenesulfonamide and total synthesis of lipogrammistin-A
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Synthesis of medium- and large-sized cyclic amines using alkylation with 2-nitrobenzenesulfonamides is described. Using either conventional alkylation procedures or Mitsunobu conditions, the cyclization reaction proceeded in a highly efficient manner. The usefulness of this methodology has been fully demonstrated in the total synthesis of lipogrammistin-A (9), an 18-membered cyclic polyamine.
- Kan, Toshiyuki,Fujiwara, Akiko,Kobayashi, Hideki,Fukuyama, Tohru
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p. 6267 - 6276
(2007/10/03)
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- A convergent total synthesis of (-)-mucocin: An acetogenin from Annonaceae
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A total synthesis of the Annonaceous acetogenin mucocin has been accomplished. The synthesis follows a convergent strategy, wherein at a very late stage the left part of the molecule is connected with the right part. The key reaction is the stereocontrolled addition of an organomagnesium compound 2 to the aldehyde 3. The THP ring of mucocin is build by a 6-endo epoxide cyclization of an epoxyacetonide precursor (16 → 17). The new modular synthetic approach developed herein should be useful for the synthesis of other related natural products as well as pharmacologically interesting analogues.
- Hoppen, Sabine,Baeurle, Stefan,Koert, Ulrich
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p. 2382 - 2396
(2007/10/03)
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