- Nitroxide-Catalyzed Oxidative Amidation of Aldehydes to Yield N-Acyl Azoles Using Sodium Persulfate
-
A methodology for the oxidative amidation of aldehydes to yield N-acyl azoles is reported. The approach employs sodium persulfate and a catalytic amount of a nitroxide and is applicable to a range of structurally diverse substrates.
- Politano, Fabrizio,León Sandoval, Arturo,Witko, Mason L.,Doherty, Katrina E.,Schroeder, Chelsea M.,Leadbeater, Nicholas E.
-
supporting information
(2021/12/23)
-
- Accessing N-Acyl Azoles via Oxoammonium Salt-Mediated Oxidative Amidation
-
An operationally simple, robust, metal-free approach to the synthesis of N-acyl azoles from both alcohols and aldehydes is described. Oxidative amidation is facilitated by a commercially available organic oxidant (4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate) and proceeds under very mild conditions for an array of structurally diverse substrates. Tandem reactions of these activated amides, such as transamidation and esterification, enable further elaboration. Also, the spent oxidant can be recovered and used to regenerate the oxoammonium salt.
- Ovian, John M.,Kelly, Christopher B.,Pistritto, Vincent A.,Leadbeater, Nicholas E.
-
supporting information
p. 1286 - 1289
(2017/03/22)
-
- Synthesis and antifungal activity evaluation of new heterocycle containing amide derivatives
-
A series of heterocycle containing amide derivatives (1-28) were synthesised by the combination of acyl chlorides (1a, 2a) and heterocyclic/homocyclic ring containing amines, and their in vitro antifungal activity was evaluated against five plant pathogenic fungi, namely Gibberella zeae, Helminthosporium maydis, Rhizoctonia solani, Botrytis cinerea and Sclerotinia sclerotiorum. Results of antifungal activity analysis indicated that some of the products showed good to excellent antifungal activity, as compound 2 showed excellent activity against G. zeae and R. solani and potent activity against H. maydi, B. cinerea and S. sclerotiorum, and compounds 1, 8 and 10 also displayed excellent antifungal potential against H. maydi, B. cinerea and S. sclerotiorum and good activity against R. solani when compared with the standard carbendazim.
- Wang, Xuesong,Gao, Sumei,Yang, Jian,Gao, Yang,Wang, Ling,Tang, Xiaorong
-
p. 682 - 688
(2016/01/28)
-
- Furoyl and thiophene carbonyl linker pyrazolyl palladium(II) complexes - Synthesis, characterization, and evaluation as ethylene oligomerization catalysts
-
Reactions of 2-furoyl chloride and 2-thiophene carbonyl chloride with substituted pyrazoles produced the modified pyrazolyl compounds: {(3,5-Me 2pzCO)-2-C4H3O} (L1), {(3,5-Me 2pzCO)-2-C4H3S
- Ojwach, Stephen O.,Tshivhase, Mmboneni G.,Guzei, Ilia A.,Darkwa, James,Mapolie, Selwyn F.
-
p. 843 - 853
(2007/10/03)
-