Synthesis and bioactivity of some new 1-tolyl-3-aryl-4-methylimidazole-2- thiones
Three series of new 1-(isomeric methyl)benzoyl-3-arylthioureas (1-3a-i) were prepared from 2-, 3-, and 4-methylbenzoyl chlorides via isothiocyanate formation followed by treatment with various substituted anilines. The base-catalyzed condensation of thiou
Saeed, Aamer,Batool, Mahira
p. 143 - 154
(2008/04/01)
Synthesis of benzoyl-N-phenylthioureas under microwave irradiation and phase transfer catalysis conditions
A simple, rapid and efficient method for the synthesis of benzoyl-N-phenylthioureas under microwave irradiation is reported. The effect of microwave irradiation power, times and phase transfer catalyst on the reaction is investigated.
THE METHANOLYSIS KINETICS AND DISSOCIATION CONSTANTS OF 1-(SUBST. BENZOYL)-3-PHENYLTHIOUREAS
A series of seven 1-(subst. benzoyl)-phenylthioureas have been prepared and their dissociation constants and solvolysis rate constant have been measured in methanol at 25 deg C.The reaction constant found show that the solvolysis rate is limited by the attack of methoxide ion on the benzoyl carbonyl group of the non-dissociated substrate.The polar effect of substituents in benzoyl group is extensively transferred also by the intramolecular hydrogen bond.