- Platinum(II) complexes of reduced amino acid ester Schiff bases: Synthesis, characterization, and antitumor activity
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A series of platinum(II) complexes of reduced amino acid esters Schiff bases were synthesized as potential anticancer agents and characterized by 1H NMR, EA, IR, and molar conductivity. These compounds were tested for their DNA interaction with salmon sperm DNA by ultraviolet spectrum and CD spectrum, and their in vitro anticancer activities have been validated against HL-60, KB, BGC-823, and Bel-7402 cell lines by MTT assay. The cytotoxicity of complexes 5d and 5f are better than cisplatin against Bel-7402 cell lines, and show a close cytotoxic effect against HL-60 cell line.
- Li, Li-Jun,Wang, Cheng,Qiao, Yu,Yang, Xiao-Yan,Hua, Xing-Xing,Du, Jian-Long
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p. 413 - 424
(2014/02/14)
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- Synthesis and characterization of the tetranuclear iron(iii) complex of a new asymmetric multidentate ligand. A structural model for purple acid phosphatases
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The ligand, 2-((2-hydroxy-5-methyl-3-((pyridin-2-ylmethylamino)methyl) benzyl)(2-hydroxybenzyl)amino)acetic acid (H3HPBA), which contains a donor atom set that mimics that of the active site of purple acid phosphatase is described. Reaction of H3HPBA with iron(iii) or iron(ii) salts results in formation of the tetranuclear complex, [Fe4(HPBA) 2(OAc)2(-O)(-OH)(OH2)2]ClO 4·5H2O. X-Ray structural analysis reveals the cation consists of four iron(iii) ions, two HPBA3- ligands, two bridging acetate ligands, a bridging oxide ion and a bridging hydroxide ion. Each binucleating HPBA3- ligand coordinates two structurally distinct hexacoordinate iron(iii) ions. The two metal ions coordinated to a HPBA 3- ligand are linked to the two iron(iii) metal ions of a second, similar binuclear unit by intramolecular oxide and hydroxide bridging moieties to form a tetramer. The complex has been further characterised by elemental analysis, mass spectrometry, UV-vis and MCD spectroscopy, X-ray crystallography, magnetic susceptibility measurements and variable-temperature Moessbauer spectroscopy. This journal is The Royal Society of Chemistry.
- Boudalis, Athanassios K.,Aston, Robyn E.,Smith, Sarah J.,Mirams, Ruth E.,Riley, Mark J.,Schenk, Gerhard,Blackman, Allan G.,Hanton, Lyall R.,Gahan, Lawrence R.
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p. 5132 - 5139
(2008/03/14)
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- Radioisotopic and synthetic studies related to caroxazone metabolism in man
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Labelled 2-oxo-2H-1,3-benzoxazine-3(4H)-acetamide (caroxazone), has been synthesized by condensing N-(2-hydroxylbenzyl)glycinamide with 14C phosgene. Metabolic studies were performed administering the labelled drug to man and recovering metabolites from the urines. Beside the unchanged drug, five metabolites were identified and confirmed by synthesis, namely (3,4-dihdydro-3-carboxamidomethyl-2-oxo-2H-1,3-benzoxazin-4-yl)urea, N-carboxamidomethyl o-hydroxymethylphenyl carbamate, 4-methoxy-2-oxo-2H-1,3-benzoxazine-3(4H)acetamide, 2-oxo-2H-1,3-benzoxazine-3(4H)acetic acid, and 4-hydroxy-2-oxo-2H-1,3-benzoxazine-3(4H)acetamide.
- Bernardi,Coda,Nicolella,Vicario,Gioia,Minghetti,Vigevani,Arcamone
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p. 1412 - 1416
(2007/10/10)
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