57938-78-0

Basic information

• Product Name: ethyl N-[(2-hydroxyphenyl)methyl]glycinate
• Synonyms: ethyl N-[(2-hydroxyphenyl)methyl]glycinate;N-(2-Hydroxyphenylmethyl)glycine ethyl ester;Einecs 261-025-2
• CAS NO: 57938-78-0
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.2417
• EINECS: 261-025-2
• Mol File: 57938-78-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 326.5°C at 760 mmHg
• Flash Point: 151.3°C
• Appearance: /
• Density: 1.146g/cm³
• Vapor Pressure: 0.000113mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: ethyl N-[(2-hydroxyphenyl)methyl]glycinate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-[(2-hydroxyphenyl)methyl]glycinate(57938-78-0)
• EPA Substance Registry System: ethyl N-[(2-hydroxyphenyl)methyl]glycinate(57938-78-0)

Safety Data

• Hazardous Substances Data: 57938-78-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H15NO3/c1-2-15-11(14)8-12-7-9-5-3-4-6-10(9)13/h3-6,12-13H,2,7-8H2,1H3

Upstream product

• 623-33-6 glycine ethyl ester hydrochloride 
• 90-02-8 salicylaldehyde 
• 66949-73-3 ethyl N-salicylideneglycinate 

Downstream Products

• 57938-79-1 N-(2-hydroxybenzyl)-glycinamide 

Relevant articles and documents

Platinum(II) complexes of reduced amino acid ester Schiff bases: Synthesis, characterization, and antitumor activity

A series of platinum(II) complexes of reduced amino acid esters Schiff bases were synthesized as potential anticancer agents and characterized by 1H NMR, EA, IR, and molar conductivity. These compounds were tested for their DNA interaction with salmon sperm DNA by ultraviolet spectrum and CD spectrum, and their in vitro anticancer activities have been validated against HL-60, KB, BGC-823, and Bel-7402 cell lines by MTT assay. The cytotoxicity of complexes 5d and 5f are better than cisplatin against Bel-7402 cell lines, and show a close cytotoxic effect against HL-60 cell line.

Radioisotopic and synthetic studies related to caroxazone metabolism in man

Labelled 2-oxo-2H-1,3-benzoxazine-3(4H)-acetamide (caroxazone), has been synthesized by condensing N-(2-hydroxylbenzyl)glycinamide with 14C phosgene. Metabolic studies were performed administering the labelled drug to man and recovering metabolites from the urines. Beside the unchanged drug, five metabolites were identified and confirmed by synthesis, namely (3,4-dihdydro-3-carboxamidomethyl-2-oxo-2H-1,3-benzoxazin-4-yl)urea, N-carboxamidomethyl o-hydroxymethylphenyl carbamate, 4-methoxy-2-oxo-2H-1,3-benzoxazine-3(4H)acetamide, 2-oxo-2H-1,3-benzoxazine-3(4H)acetic acid, and 4-hydroxy-2-oxo-2H-1,3-benzoxazine-3(4H)acetamide.