- Conformational Equilibrium in (Cyclopropylmethyl)acetylene: A Microwave Spectroscopy and ab Initio Calculation Study
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The microwave spectrum of (cyclopropylmethyl)acetylene (a newly prepared compound) was investigated in the frequency range 28-40 GHz.Both gauche and cis conformers were observed, the latter being 64 +/- 30 cm-1 lower in energy.The geometries of these conformers were obtained combining the ab initio and microwave spectroscopy results.A large-amplitude motion (the methylacetylene group torsion) was studied by assigning the rotational spectra of several torsionally excited states.
- Caminati, Walther,Danieli, Roberto,Dakkouri, Marwan,Bitschenauer, Ralf
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- TRIAZOLE-PYRIDINYL SUBSTITUTED AZACYCLOHEXYL ACETIC ACID COMPOUNDS AS LPA RECEPTOR ANTAGONISTS
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This application relates to novel substituted azacyclohexyl acetic acid compounds, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with dysregulation of lysophosphatidic acid receptors (LPA).
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Paragraph 0498
(2022/02/28)
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- ASPARTYL PROTEASE INHIBITORS
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A compound of formula (I) N-oxides, addition salts, quaternary amines metal complexes stereochemically isomeric forms and metabolites thereof, wherein A is CR1 Or N; formula (A) or formula (B) D is H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, G is NR10 or O Q is C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6Cycloalkyl, aryl or heterocyclyl; W is H, C1-C6alkyl, C3-C6Cycloalkyl, CH2F, CHF2 or CF3; one of X' and X" is H or CH3, the other is C1-C3alkyl, F, OH, NRaRb, CF3 or N3; or X' and X" are both F; Y is NRd or O; Z is O, NRa, CHRd, CF2 or S(=0)r or a bond; the other variables are as defined in the specification. The compounds of the invention are inhibitors of BACE and are among other things useful for the treatment and/or prevention of conditions associated with BACE activity such as Alzheimer's disease.
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Page/Page column 102-103
(2010/10/03)
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