58405-37-1

Basic information

• Product Name: prop-2-ynylcyclopropane
• Synonyms: prop-2-ynylcyclopropane;PROP-2-YNYLCYCLOPROPANE, 50% IN 1,1,1,3,3,3-HEXAMETHYLDISOLOXANE
• CAS NO: 58405-37-1
• Molecular Formula: C₆H₈
• Molecular Weight: 80
• Mol File: 58405-37-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 72.0±9.0 °C(Predicted)
• Appearance: /
• Density: 0.879±0.06 g/cm3(Predicted)
• CAS DataBase Reference: prop-2-ynylcyclopropane(CAS DataBase Reference)
• NIST Chemistry Reference: prop-2-ynylcyclopropane(58405-37-1)
• EPA Substance Registry System: prop-2-ynylcyclopropane(58405-37-1)

Safety Data

• Hazardous Substances Data: 58405-37-1(Hazardous Substances Data)

Upstream product

• 7051-34-5 cyclopropylcarbinyl bromide 
• 1066-54-2 trimethylsilylacetylene 
• 6542-60-5 2-cyclopropylacetonitrile 
• 4160-75-2 1-cyclopropylpropan-2-one 
• 1216963-74-4 lithium acetylide-ethylenediamine complex 
• 53620-19-2 1-(Cyclopropylmethyl)-vinyl-triflat 

Relevant articles and documents

Conformational Equilibrium in (Cyclopropylmethyl)acetylene: A Microwave Spectroscopy and ab Initio Calculation Study

The microwave spectrum of (cyclopropylmethyl)acetylene (a newly prepared compound) was investigated in the frequency range 28-40 GHz.Both gauche and cis conformers were observed, the latter being 64 +/- 30 cm-1 lower in energy.The geometries of these conformers were obtained combining the ab initio and microwave spectroscopy results.A large-amplitude motion (the methylacetylene group torsion) was studied by assigning the rotational spectra of several torsionally excited states.

ASPARTYL PROTEASE INHIBITORS

A compound of formula (I) N-oxides, addition salts, quaternary amines metal complexes stereochemically isomeric forms and metabolites thereof, wherein A is CR1 Or N; formula (A) or formula (B) D is H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, G is NR10 or O Q is C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6Cycloalkyl, aryl or heterocyclyl; W is H, C1-C6alkyl, C3-C6Cycloalkyl, CH2F, CHF2 or CF3; one of X' and X" is H or CH3, the other is C1-C3alkyl, F, OH, NRaRb, CF3 or N3; or X' and X" are both F; Y is NRd or O; Z is O, NRa, CHRd, CF2 or S(=0)r or a bond; the other variables are as defined in the specification. The compounds of the invention are inhibitors of BACE and are among other things useful for the treatment and/or prevention of conditions associated with BACE activity such as Alzheimer's disease.