- Microwave-Assisted Synthesis, Antimicrobial, and Cytotoxicity Activity of N-tert-butyl-3-{[2-(arylamino)pyrimidin-4-yl]amino} Benzenesulfonamides
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A novel synthetic method has been developed with palladium-catalyzed Buchwald–Hartwig-type reaction for the synthesis of N-tert-butyl-3-{[2-(arylamino)pyrimidin-4-yl]amino} benzenesulfonamide 5 by the treatment of N-tert-butyl-3-[(2-chloropyrimidin-4-yl)a
- Patwari, Shivaji B.,Murali, Medari S.,Jadhav, Vivekanand B.
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- USP30 INHIBITORS AND USES THEREOF
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The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of USP30, and the treatment of USP30-mediated disorders.
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- Diphenylamino pyrimidine compound for inhibiting kinase activity
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The invention provides a diphenylamino pyrimidine compound for inhibiting the kinase activity, and particularly provides a medicinal composition of a substituted diphenylamino pyrimidine compound andapplication thereof. The compound is a compound as shown in a formula (I) in the specification, or pharmaceutically acceptable salt, prodrug, hydrate thereof or solvent compound, crystal form, N-oxideand various diastereomers thereof. The compound can be used for treating diseases which can be treated with JAK2 kinase inhibitors.
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- POTENT DUAL BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS
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Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.
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