608523-94-0

Basic information

• Product Name: 3-AMINO-N-(TERT-BUTYL)BENZENESULFONAMIDE
• Synonyms: ASINEX-REAG BAS 12543307;3-AMINO-N-T-BUTYLBENZENESULFONAMIDE;3-AMINO-N-(TERT-BUTYL)BENZENESULFONAMIDE;N-T-BUTYL 3-AMINOBENZENESULFONAMIDE;N-tert-Butyl 3-Aminophenylsulfonamide;BenzenesulfonaMide, 3-aMino-N-(1,1-diMethylethyl)-;N-tertbutyl-3-aminobenzensulfonmide
• CAS NO: 608523-94-0
• Molecular Formula: C10H16N2O2S
• Molecular Weight: 228.31
• Product Categories: Amines;blocks;Sulfonamides;Amines and Anilines;Boron, Nitrile, Thio,& TM-Cpds
• Mol File: 608523-94-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 387.3 °C at 760 mmHg
• Flash Point: 188 °C
• Appearance: /
• Density: 1.189 g/cm³
• Vapor Pressure: 3.33E-06mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 12.23±0.50(Predicted)
• CAS DataBase Reference: 3-AMINO-N-(TERT-BUTYL)BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-N-(TERT-BUTYL)BENZENESULFONAMIDE(608523-94-0)
• EPA Substance Registry System: 3-AMINO-N-(TERT-BUTYL)BENZENESULFONAMIDE(608523-94-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 608523-94-0(Hazardous Substances Data)

Usage

Uses

3-Amino-N-(Tertbutylbenzenesulfonamide can be used USP30 inhibitors.

InChI:InChI=1/C10H16N2O2S/c1-10(2,3)12-15(13,14)9-6-4-5-8(11)7-9/h4-7,12H,11H2,1-3H3

Upstream product

• 121-51-7 3-nitrobenzenesulphonyl chloride 

Downstream Products

• 1028253-09-9 N-(3-(tert-butylsulfamoyl)phenyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide 
• 1028253-12-4 3-methyl-N-(3-sulfamoylphenyl)-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide 
• 936092-53-4 N-(tert-butyl)-3-((2-chloro-5-methylpyrimidin-4-yl)amino)benzenesulfonamide 

Relevant articles and documents

Microwave-Assisted Synthesis, Antimicrobial, and Cytotoxicity Activity of N-tert-butyl-3-{[2-(arylamino)pyrimidin-4-yl]amino} Benzenesulfonamides

A novel synthetic method has been developed with palladium-catalyzed Buchwald–Hartwig-type reaction for the synthesis of N-tert-butyl-3-{[2-(arylamino)pyrimidin-4-yl]amino} benzenesulfonamide 5 by the treatment of N-tert-butyl-3-[(2-chloropyrimidin-4-yl)a

Diphenylamino pyrimidine compound for inhibiting kinase activity

The invention provides a diphenylamino pyrimidine compound for inhibiting the kinase activity, and particularly provides a medicinal composition of a substituted diphenylamino pyrimidine compound andapplication thereof. The compound is a compound as shown in a formula (I) in the specification, or pharmaceutically acceptable salt, prodrug, hydrate thereof or solvent compound, crystal form, N-oxideand various diastereomers thereof. The compound can be used for treating diseases which can be treated with JAK2 kinase inhibitors.