cas 6200-60-8, IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID | Articles data ｜lookchem

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6200-60-8

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Discovery of potent colony-stimulating factor 1 receptor inhibitors by replacement of hinge-binder moieties
Tumor-associated macrophages (TAMs) are predominantly associated with tumor growth. Colony-stimulating factor 1 receptor (CSF1R) acts as a key regulator of TAM survival and differentiation and is a molecular target for cancer therapies. Herein, novel CSF1
Lee, Jung Wuk,Park, Jiwon,Kim, Jina,Kim, Jihyung,Choi, Changyu,Min, Kyung Hoon
(2021/03/14)

Identification of fused bicyclic heterocycles as potent and selective 5-HT2A receptor antagonists for the treatment of insomnia
A series of fused bicyclic heterocycles was identified as potent and selective 5-HT2A receptor antagonists. Optimization of the series resulted in compounds that had improved PK properties, favorable CNS partitioning, good pharmacokinetic properties, and significant improvements on deep sleep (delta power) and sleep consolidation.
Xiong, Yifeng,Ullman, Brett,Choi, Jin-Sun Karoline,Cherrier, Martin,Strah-Pleynet, Sonja,Decaire, Marc,Feichtinger, Konrad,Frazer, John M.,Yoon, Woo H.,Whelan, Kevin,Sanabria, Erin K.,Grottick, Andrew J.,Al-Shamma, Hussien,Semple, Graeme
scheme or table
p. 1870 - 1873
(2012/04/17)

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Chemical Properties

Appearance/Colour :Off white Solid
Melting Point: 196 °C
Density: 1.41 g/cm³
Storage Temp.:Sealed in dry,Room Temperature
Refractive Index: 1.564
PKA: -0.61±0.41(Predicted)
PSA: 54.60000
LogP: 1.03250

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