Catalytic asymmetric synthesis of Pt- and Pd-PCP pincer complexes bearing a para-N pyridinyl backbone
A diastereoselective catalytic asymmetric hydrophosphination reaction was performed using a palladacycle catalyst to produce chiral PCP phosphine ligand with high dr (95:5) and excellent enantioselectivity (>99% ee). Subsequent facile metalation of the ch
Yen Wong, Esther Hui,Jia, Yu-Xiang,Li, Yongxin,Pullarkat, Sumod A.,Leung, Pak-Hing
p. 22 - 27
(2018/03/21)
Appending a tris-imidazole ligand with a Tyr244 mimic on the distal face of bromoacetamidoporphyrin
(Equation presented) Bromoacetamidoporphyrin is a convenient synthon for the attachment of distal superstructures at room temperature in good yields. New models are presented that contain a tris-imidazole distal ligand set bound to the porphyrin in either a binary or trinary fashion. More importantly, one distal imidazole is cross-linked to a phenol mimicking Tyr244, making this model the closest structural analogue yet reported of the metal free cytochrome c oxidase (CcO) active site.
Collman, James P.,Decreau, Richard A.,Costanzo, Simona
p. 1033 - 1036
(2007/10/03)
A general method for coupling unprotected peptides to bromoacetamido porphyrin templates
An N-terminal cysteine is used to displace bromide from a bromoacetylated porphyrin to yield a thioether linkage between the peptide and the template. Unlike amide coupling reactions, this approach should be compatible with any peptide sequence provided there is only a single cysteine.
Choma, Christin T.,Kaestle, Karen,Akerfeldt, Karin S.,Kim, Ronald M.,Groves, John T.,DeGrado, William F.
p. 6191 - 6194
(2007/10/02)
More Articles about upstream products of 6221-04-1