An efficient synthesis of 3-substituted 3H-pyrimidin-4-ones
(Equation presented) A novel and practical synthesis of 3-substituted 3H-pyrimidin-4-ones is described. The key step involves the cyclization of enamide esters, derived from readily available β-keto esters, with trimethylaluminum and various primary amines.
Jeong, Jae Uk,Chen, Xiaohong,Rahman, Attiq,Yamashita, Dennis S.,Luengo, Juan I.
p. 1013 - 1016
(2007/10/03)
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