cas 63010-72-0, 4-Chloro-8-fluoroquinoline | Articles data ｜lookchem

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63010-72-0

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AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES
Compounds are provided that act as potent antagonists of the CCR(9) receptor for treating Sjogren's syndrome. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions.
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Paragraph 0128; 0129

(2018/02/28)

AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES
Compounds are provided that act as potent antagonists of the CCR(9) receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR(9). The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR(9)-mediated diseases, and as controls in assays for the identification of CCR(9) antagonists.
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Paragraph 0131; 0132

(2013/09/12)

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities
A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2.
Madrid, Peter B.,Sherrill, John,Liou, Ally P.,Weisman, Jennifer L.,DeRisi, Joseph L.,Guy, R. Kiplin
p. 1015 - 1018
(2007/10/03)

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Chemical Properties

Melting Point: 1.366 g/cm³
Boiling Point: 259.9 °C at 760 mmHg
Flash Point:259.9 °C at 760 mmHg
Density: 1.366 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
PSA: 12.89000
LogP: 3.02730

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