63010-72-0

Basic information

• Product Name: 4-Chloro-8-fluoroquinoline
• Synonyms: IFLAB-BB F2108-0070;BUTTPARK 20\09-08;4-CHLORO-8-FLUOROQUINOLINE;8-FLUORO-4-CHLOROQUINOLINE;4-Chloro-8-fluoroquinolline
• CAS NO: 63010-72-0
• Molecular Formula: C₉H₅ClFN
• Molecular Weight: 181.59
• Mol File: 63010-72-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 97.0 to 101.0 °C
• Boiling Point: 259.9 °C at 760 mmHg
• Flash Point: 259.9 °C at 760 mmHg
• Appearance: /
• Density: 1.366 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-Chloro-8-fluoroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-8-fluoroquinoline(63010-72-0)
• EPA Substance Registry System: 4-Chloro-8-fluoroquinoline(63010-72-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 63010-72-0(Hazardous Substances Data)

Usage

Uses

4-Chloro-8-fluoroquinoline is used as an intermediate in organic synthesis.

Upstream product

• 63010-71-9 8-fluoro-4-hydroxyquinoline 
• 148401-38-1 4-amino-8-fluoroquinoline 
• 369395-32-4 5-[(2-fluoro-phenylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione 

Downstream Products

• 693818-07-4 2'-fluoro-5'-(8-fluoroquinolin-4-yl)biphenyl-2-carbonitrile 
• 49611-99-6 8-fluoro-4-hydrazinylquinoline 
• 1452182-61-4 4-tert-butyl-N-(1-(8-fluoroquinolin-4-yl)-3-methyl-1H-pyrazol-5-yl)benzenesulfonamide 
• 124534-44-7 4,8-bis[2-(4-methylphenyl)ethoxy]quinoline 
• 124533-55-7 8-fluoro-N-[2-(2-naphthyl)ethyl]-4-quinolinamine 
• 124533-68-2 8-fluoro-N-[2-(thien-2-yl)ethyl]-4-quinolinamine 
• 949535-30-2 4-cyano-8-fluoro-quinoline 

Relevant articles and documents

AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES

Compounds are provided that act as potent antagonists of the CCR(9) receptor for treating Sjogren's syndrome. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions.

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2.