- Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics
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Protein-protein interactions (PPIs) mediate cellular pathways and are implicated in numerous aberrant conditions. α-Helix mimetics - small molecules that reproduce the spatial projection of key residues from an α-helix involved in a PPI - are attractive generic templates for development of screening libraries, however library syntheses of α-helix mimetics with diverse functionality are less established. This manuscript describes the automated, microwave assisted solid phase synthesis based on one such scaffold; an N-alkylated oligobenzamide.
- Long, Kérya,Edwards, Thomas A.,Wilson, Andrew J.
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p. 4034 - 4040
(2013/07/27)
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- Potential antiatherosclerotic agents. 2. (Aralkylamino)- and (alkylamino)benzoic acid analogues of cetaben
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The syntheses of a series of (aralkylamino)- and (alkylamino)benzoic acids, as well as the corresponding esters and sodium salts, are described. The compounds were evaluated in vivo in rats for serum sterol and triglyceride lowering activity and in vitro
- Albright,DeVries,Largis,Miner,Reich,Schaffer,Shepherd,Upeslacis
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p. 1378 - 1393
(2007/10/02)
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- Hypolipidaemic compounds and compositions
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Certain substituted aralkylanilines in which the aromatic aniline ring carries, at the para position to the amino function, a substituent which comprises a carboxylic acid, salt or ester, an alkyl, hydroxyalkyl, cyano or acyl group, have hypolipidaemic ac
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