- Acylthiourea compound, preparation method thereof and application of acylthiourea compound in resisting influenza A viruses
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The invention discloses an acylthiourea compound, a preparation method thereof and application of the acylthiourea compound in resisting influenza A viruses. Substituted aromatic formyl chloride compounds, amine thiocyanate and substituted aromatic hetero
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Paragraph 0032-0035
(2019/12/02)
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- HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES
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Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.
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Paragraph 000499
(2016/05/02)
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- IMINOSUGARS USEFUL FOR THE TREATMENT OF VIRAL DISEASES
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Formula IA, ad their use for treating viral infections.
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Page/Page column 61
(2016/06/01)
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- Five-And-Six-Membered Heterocyclic Compound, And Preparation Method, Pharmaceutical Composition And Use Thereof
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A five-and-six-membered heterocyclic compound as represented by general formula I, pharmaceutically acceptable salt, metabolite, metabolic precursors or drug precursors thereof, preparation method, pharmaceutical composition, and use thereof; the five-and-six-membered heterocyclic compound has activity as a Janus kinase (JAK) inhibitor, and can be used to prepare drugs for treating diseases caused by the abnormal activity of kinase, such as cell proliferation diseases like cancer.
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Paragraph 0160; 0162
(2015/12/07)
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- Highly active recyclable heterogeneous Pd/ZnO nanoparticle catalyst: Sustainable developments for the C-O and C-N bond cross-coupling reactions of aryl halides under ligand-free conditions
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Efficient Pd supported on ZnO nanoparticles for the ligand-free O-arylation and N-arylation of phenols and various N-H heterocycles with aryl chlorides, bromides, and iodides were readily synthesized and characterized. The amount of palladium on ZnO is 9.84 wt% (0.005 g of the catalyst contains 462 × 10-8 mol% of Pd) which was determined by ICP analysis. This nano sized Pd/ZnO with an average particle size of 20-25 nm and specific surface area 40.61 m2 g-1 was used as a new reusable heterogeneous catalyst for the formation of C-O and C-N bonds in organic synthesis. This protocol gives the arylated product in satisfactory yields without any N2 or Ar flow. The catalyst can be recovered and recycled several times without marked loss of activity.
- Hosseini-Sarvari, Mona,Razmi, Zahra
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p. 44105 - 44116
(2014/12/10)
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- Synthesis of novel heteroarenes based [1,2,3]-triazoles via click chemistry and their evaluation for antibacterial activity
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A series of heteroarenes based [1,2,3]-triazole derivatives 8a-h and 9a-f has been synthesized via click chemistry through Huisgen [2+3] cycloaddition reaction of heteroarylazides 7a-e with alkynes (3a-c, propargyl alcohol or phenyl acetylene) in the presence of CuSO4.5H2O and sodium ascorbate in t-butanol and water (1:1) mixture at 25°C in good to excellent yields (74-94%). All the newly synthesized compounds have been characterized on the basis of analytical and spectral data. The compounds 8a, 8e, 9a, 9b, 9c and 9e have been evaluated for their preliminary in-vitro antibacterial efficacy against a panel of two Gram-positive bacteria viz. Staphylococcus aureus and Streptococcus mutans and two Gramnegative bacteria viz. Escherichia coli and Pseudomonas aeruginosa using the Agar disc diffusion method.
- Prasad, Davinder,Aggarwal, Nisha,Kumar, Rajesh,Nath, Mahendra
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scheme or table
p. 731 - 738
(2012/07/02)
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- IMIDAZOQUINOLINES AS LIPID KINASE INHIBITORS
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The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.
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Page/Page column 68; 69
(2008/06/13)
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- Amide thiadiazole inhibitors of plasminogen activator inhibitor-1
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Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula at least one compound of formula (I), or a ph
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Page/Page column 23-24
(2010/02/12)
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- Optically active antifungal azoles. X. Synthesis and antifungal activity of N-[4-(azolyl)phenyl]- and N-[4-(azolylmethyl)phenyl]-N′-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy -1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-azolones
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New optically active antifungal azoles, N-[4-(azolyl)phenyl]- and N-[4-(azolylmethyl)phenyl]-N′-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy -1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]azolones (1, 2, 3), were prepared in a stereocontrolled manner. Compounds 1
- Kitazaki, Tomoyuki,Ichikawa, Takashi,Tasaka, Akihiro,Hosono, Hiroshi,Matsushita, Yoshihiro,Hayashi, Ryogo,Okonogi, Kenji,Itoh, Katsumi
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p. 1935 - 1946
(2007/10/03)
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- FT-IR and 13C-NMR Correlations for Some N-Substituted Azoles and Benzazoles
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The FT-IR (in carbon tetrachloride) and 13C-NMR (in deuterochloroform) spectra of six p-substituted aniline derivatives, as reference compounds, and nine 1-p-aminophenyl-azoles and benzazoles were recorded.The mesured spectral parameters from FT-IR were s
- Elguero, Jose,Gil, Manuel,Iza, Nerea,Pardo, Carmen,Ramos, Mar
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p. 1111 - 1119
(2007/10/02)
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- SUBSTITUTED HETEROCYCLYL-PHENYL-(SULFONYL-OR PHOSPHONYL)-AMIDINES
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Compounds of the formula STR1 wherein Het is a heterocycle containing 2 to 3 nitrogen atoms;R is hydrogen, lower alkyl, alkoxy of 1 to 3 carbon atoms or halogen;Y is--SO 3 H or STR2 R" is alkyl of 1 to 3 carbon atoms; and R' is straight or branched alkyl which may contain a heteroatom such as sulfur, oxygen or nitrogen; straight or branched alkenyl; cycloalkyl; alkyl-cycloalkyl; aryl; or aralkyl optionally substituted by lower alkyl, alkoxy of 1 to 3 carbon atoms or halogen; tautomers thereof, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics and gastric acid secretion inhibitors. "
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