- Chloro-oxime derivatives as novel small molecule chaperone amplifiers
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Chloro-oxime derivatives were investigated as novel small molecule chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC50 10 μM).
- Zhou, Yuefen,Vu, Khang,Chen, Yongsheng,Pham, John,Brady, Thomas,Liu, Gang,Chen, Jinhua,Nam, Joonwoo,Murali Mohan Reddy,Au, Qingyan,Yoon, Il Sang,Tremblay, Marie-Helene,Yip, Gary,Cher, Charmian,Zhang, Bin,Barber, Jack R.,Ng, Shi Chung
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scheme or table
p. 3128 - 3135
(2010/01/16)
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- BENZOFURYL DERIVATIVES AND THEIR USE
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The invention is concerned with the use of compounds of general formula (I) wherein R1-R4signify hydrogen, halogen, lower-alkyl, lower-alkoxy, aryl, benzyloxy, lower-alkoxy-lower-alkyl, lower-alkyl-sulphanyl, lower-alkyl-sulphanyl-lower-alkyl or R1and R2t
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- METHOD OF TREATING DISEASES OF THE CNS
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The invention is concerned with the use of compounds of the general formula STR1 wherein R 1-R 4 signify hydrogen, halogen, lower-alkyl, lower-alkoxy, aryl, benzyloxy, lower-alkoxy-lower-alkyl, lower-alkyl-sulphanyl, lower-alkyl-sulphanyl-lower-alkyl or R
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- Analgesic and antiinflammatory properties of 2-benzofuran amidoximes
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2-Benzofuran carboximidamide and various of its substituted derivatives have been tested for analgesic, anti-inflammatory and ulcerigeneous activity. For comparison, the same tests were performed with 2-naphto[2,1-b]furan carboximidamide, some 3-benzopyrancarboximidamides and 2-furan carboximidamide. Most 2-benzofurancarboximidamides show to have interesting analgesic properties. Some of them are also anti-inflammatories. 3-Methyl-5-bromo-2-benzofurancarboximidamide can be compared to aspirin and phenylbutazone as analgesic and anti-inflammatory respectively; no significant ulcerigeneous effect was noted for this compound.
- Riffaud,Dupont,Rene,Royer
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p. 577 - 581
(2007/10/02)
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