65695-07-0

Basic information

• Product Name: 2-Benzofurancarboximidamide,N-hydroxy-
• Synonyms: 2-Benzofurancarboximidamide,N-hydroxy-;2-Benzofurancarboximidamide,N-hydroxy-(9CI);2-Benzofurancarboxamide oxime;Brn 0006957;N-Hydroxy-2-benzofurancarboximidamide
• CAS NO: 65695-07-0
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17202
• Product Categories: AMIDINE
• Mol File: 65695-07-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 378.1 °C at 760 mmHg
• Flash Point: 182.5 °C
• Appearance: /
• Density: 1.4 g/cm³
• CAS DataBase Reference: 2-Benzofurancarboximidamide,N-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzofurancarboximidamide,N-hydroxy-(65695-07-0)
• EPA Substance Registry System: 2-Benzofurancarboximidamide,N-hydroxy-(65695-07-0)

Safety Data

• Hazardous Substances Data: 65695-07-0(Hazardous Substances Data)

Usage

General Description

2-Benzofurancarboximidamide, N-hydroxy- is a chemical compound with the molecular formula C9H7N3O2. It is a derivative of benzofuran, containing an imidamide group that is substituted with a hydroxy group at the N-position. This chemical is known to exhibit antitumor and cytotoxic activities, making it a potential candidate for the development of new cancer therapies. Its specific mechanism of action and potential therapeutic applications are still under investigation, but its unique structure and pharmacological properties make it an interesting subject for further research in the field of medicinal chemistry and drug development.

Upstream product

• 41717-32-2 benzofuran-2-carbonitrile 

Relevant articles and documents

Chloro-oxime derivatives as novel small molecule chaperone amplifiers

Chloro-oxime derivatives were investigated as novel small molecule chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC50 10 μM).

METHOD OF TREATING DISEASES OF THE CNS

The invention is concerned with the use of compounds of the general formula STR1 wherein R 1-R 4 signify hydrogen, halogen, lower-alkyl, lower-alkoxy, aryl, benzyloxy, lower-alkoxy-lower-alkyl, lower-alkyl-sulphanyl, lower-alkyl-sulphanyl-lower-alkyl or R

Analgesic and antiinflammatory properties of 2-benzofuran amidoximes

2-Benzofuran carboximidamide and various of its substituted derivatives have been tested for analgesic, anti-inflammatory and ulcerigeneous activity. For comparison, the same tests were performed with 2-naphto[2,1-b]furan carboximidamide, some 3-benzopyrancarboximidamides and 2-furan carboximidamide. Most 2-benzofurancarboximidamides show to have interesting analgesic properties. Some of them are also anti-inflammatories. 3-Methyl-5-bromo-2-benzofurancarboximidamide can be compared to aspirin and phenylbutazone as analgesic and anti-inflammatory respectively; no significant ulcerigeneous effect was noted for this compound.