- Synthesis of deuterium-labelled drugs by hydrogen-deuterium (H-D) exchange using heterogeneous catalysis
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Multi-deuterium incorporations into drugs, such as theophylline, caffeine, valpromide, phenytoin, and trimethoprim, were post-synthetically achieved by Pd/C-, Pt/C-, or/and Rh/C-catalyzed hydrogen-deuterium exchange reactions under neutral conditions usin
- Modutlwa, Nkaelang,Maegawa, Tomohiro,Monguchi, Yasunari,Sajiki, Hironao
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experimental part
p. 686 - 692
(2011/09/16)
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- Superacid Activated Condensation of Parabanic Acid and Derivatives with Arenes. A New Synthesis of Phenytoin and 5,5-Diarylhydantoins
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A new synthetic route to phenytoin and 5,5-diarylhydantoins is repoted.Parabanic acid is converted to the 5,5-diarylhydantoins (65-98percent yield) from CF3SO3H and arenes.Deuterium substituted products are prepared in high yield from parabanic acid, CF3SO3D, and deuterated arenes.
- Klumpp, Douglas A.,Yeung, Ka Yeun,Prakash, G. K. Surya,Olah, George A.
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p. 918 - 920
(2007/10/03)
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