65854-97-9 Usage
Chemical Properties
5,5-DIPHENYL-D10-HYDANTOIN is White Crystalline Solid
Uses
Different sources of media describe the Uses of 65854-97-9 differently. You can refer to the following data:
1. 5,5-DIPHENYL-D10-HYDANTOIN reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels.
2. Labeled Phenytoin, intended for use as an internal standard for the quantification of Phenytoin by GC- or LC-mass spectrometry.
3. 5,5-(Diphenyl-d10) Hydantoin is deuterium labelled Diphenylhydantoin (D491650), which is an anticonvulsant agent that suppresses abnormal brain activity associated with seizure. Diphenylhydantoin is used to treat ulcers, epidermolysis bullosa, chorea, Parkinson’s syndrome, trigeminal neuralgia, acute alcoholism, and inflammatory conditions (1,2).
General Description
A Certified Spiking Solution? suitable for use as an internal standard in LC/MS or GC/MS phenytoin testing methods for clinical toxicology, forensic analysis, urine drug testing,?medication monitoring, or pharmaceutical research applications. Phenytoin is an antiepileptic drug used in the prevention and treatment of seizures.
Check Digit Verification of cas no
The CAS Registry Mumber 65854-97-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,8,5 and 4 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 65854-97:
(7*6)+(6*5)+(5*8)+(4*5)+(3*4)+(2*9)+(1*7)=169
169 % 10 = 9
So 65854-97-9 is a valid CAS Registry Number.
65854-97-9Relevant articles and documents
Synthesis of deuterium-labelled drugs by hydrogen-deuterium (H-D) exchange using heterogeneous catalysis
Modutlwa, Nkaelang,Maegawa, Tomohiro,Monguchi, Yasunari,Sajiki, Hironao
experimental part, p. 686 - 692 (2011/09/16)
Multi-deuterium incorporations into drugs, such as theophylline, caffeine, valpromide, phenytoin, and trimethoprim, were post-synthetically achieved by Pd/C-, Pt/C-, or/and Rh/C-catalyzed hydrogen-deuterium exchange reactions under neutral conditions usin
A convenient synthesis of deuterium labelled diphenylhydantoin
Casey,Gwilt,Digenis,Perrier
, p. 623 - 625 (2007/10/09)
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