- Synthesis, mechanism and efficient modulation of a fluorescence dye by photochromic pyrazolone with energy transfer in the crystalline state
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A dual-responsive photochromic compound, 1,3-diphenyl-4-(3-chloro-4-pyridylformyl)-5-hydroxypyrazole 4-phenylsemicarbazone (1) based on a pyrazolone derivative with excellent reversible photochromic reactions in the crystalline state, was successfully synthesized. The new photochromic mechanism of 1 is attributed to isomerization between the enol form and keto form with proton transfer, which was confirmed by IR, XPS, crystal structure data and theoretical calculation. In order to achieve high-contrast fluorescence switch capability, two-component composite materials (TCCM) were prepared by co-aggregating. The emission intensity of fluorophore 9,10-diphenylanthracene (DPA) can be efficiently switched by the fluorescence resonance energy transfer (FRET) between the donor DPA and acceptor coloured 1 in TCCM. The fluorescence modulation ratio is found to be 79%, which is influenced by changing the content of DPA. This novel photoswitchable TCCM may have potential application as photoswitches.
- Li, Yinhua,Guo, Jixi,Liu, Anjie,Jia, Dianzeng,Wu, Xueyan,Chen, Yi
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- Efficient Synthesis of Five Types of Heterocyclic Compounds via Intramolecular Elimination Using Ultrasound-Static Heating Technique
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An experimental technique, ultrasound-static heating, has been developed for the efficient synthesis of heterocyclic compounds. The technique involves ultrasonic irradiation and static heating processes. First, the ultrasonic irradiation process is performed to form an intermediate of the heterocyclic compound under mild conditions and the subsequent static heating process (heating the intermediate under solvent-free conditions without stirring) produces the target heterocyclic compounds via intramolecular elimination.
- Jiang, Hongfei,Dong, Xueyang,Jin, Xin,Zhu, Danyang,Yin, Ruijuan,Yu, Rilei,Wan, Shengbiao,Zhang, Lijuan,Jiang, Tao
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p. 2009 - 2013
(2018/07/31)
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- PYRAZOLONE DERIVATIVE HAVING CYCLIC SIDE CHAIN
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PROBLEM TO BE SOLVED: To provide a compound that has excellent inhibitory action on ATPase activity of TIP48/TIP49 complex and is therefore useful for the treatment of tumor, or a pharmacologically acceptable salt thereof. SOLUTION: The present invention provides a compound having a structure represented by general formula (I), its pharmacologically acceptable salt, or a pharmaceutical composition comprising the compound (where R1, R2, R3, R4, R5, R6, R7, W, and Z are as defined in the specifications). SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
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Paragraph 0282; 0283
(2016/10/08)
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- Room-temperature direct alkenylation of 5-pyrazolones
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A mild and efficient method for the direct alkenylation of 5-pyrazoles by Pd-catalyzed C-H bond activation is described. The reaction smoothly proceeds at room temperature to provide products in up to 92 % yield. Heterocycles containing the 5-pyrazolone moiety are synthesized by an oxidative Heck-type reaction. The direct alkenylation of 5-pyrazolones at room temperature through Pd-catalyzed C-H bond activation is described. Copyright
- Yang, Yiwen,Gong, Hao,Kuang, Chunxiang
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supporting information
p. 5276 - 5281
(2013/09/02)
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- Organotin(IV) derivatives of novel β-diketones: Part V. Synthesis and characterization of di- and triorganotin(IV) derivatives of 4-acyl-5-pyrazolones modified in position 3 of the pyrazole. Crystal structure of (1,3-diphenyl-4-benzoyl-pyrazolon-5-ato)tri
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The interaction between R3SnCl, (R3Sn)2O, R2SnO or R2SnCl2 acceptors (R = Me, nBu or Ph) and the two novel β-diketone proligands (LH = 1,3-diphenyl-4-R4(C=O)-pyrazol-5
- Marchetti, Fabio,Pettinari, Claudio,Cingolani, Augusto,Pettinari, Riccardo,Rossi, Miriam,Caruso, Francesco
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p. 134 - 145
(2007/10/03)
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- RECYCLIZATION OF 4-METHYL(PHENYL)-2,3-DIHYDRO-1H-1,5-BENZODIAZEPIN-2-ONES
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Depending on the reaction conditions, the hydrazinolysis of 4-(acetyl-methylene)-1,2,3,5-tetrahydro-1,5-benzodiazepin-2-one affords N-(2-aminophenyl)-5-methyl-3-pyrazolylacetamide or 2-benzimidazo-5-methyl-3-pyrazolylmethane.In the presence of phenylhydrazine, 3,4,5-trimethyl-1,5-benzodiazepine is recyclized to 3,4,5-trimethyl-1-phenyl-2-pyrazole.
- Gaponov, A. A.,Solomko, Z. F.,Bozhanova, N. Ya.,Pantyukh, E. I.
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- Mechanisms of Heterocycle Ring Formation. Part 5. A Carbon-13 Nuclear Magnetic Resonance Study of Pyrazolinone Synthesis by the Reaction of β-Ketoesters with Substituted Hydrazines
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The 16 reactions between each of four hydrazines and four β-ketoesters have been followed by 13C n.m.r. spectroscopy.Peaks were assigned to starting materials, intermediates, and products, and reaction mechanisms determined and rationalized.Most rections proceed by attack of the least hindered hydrazine nitrogen atom on the keto carbon group of the ketoester.Relative rates of nucleophilic attack determine the build-up of intermediate and in some cases the nature of the products formed.
- Katrizky, Alan R.,Barczynski, Piotr,Ostercamp, Daryl L.
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p. 969 - 976
(2007/10/02)
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