6632-05-9

Basic information

• Product Name: 1,2-Dihydro-2,5-diphenyl-3H-pyrazol-3-one
• Synonyms: 1,2-Dihydro-2,5-diphenyl-3H-pyrazol-3-one;2-phenyl-5-phenyl-pyrazol-3-one
• CAS NO: 6632-05-9
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.2686
• Mol File: 6632-05-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 137-139 °C
• Boiling Point: 388.8°Cat760mmHg
• Flash Point: 188.9°C
• Appearance: /
• Density: 1.23g/cm³
• PKA: -0.74±0.40(Predicted)
• CAS DataBase Reference: 1,2-Dihydro-2,5-diphenyl-3H-pyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Dihydro-2,5-diphenyl-3H-pyrazol-3-one(6632-05-9)
• EPA Substance Registry System: 1,2-Dihydro-2,5-diphenyl-3H-pyrazol-3-one(6632-05-9)

Safety Data

• Hazardous Substances Data: 6632-05-9(Hazardous Substances Data)

Usage

Uses

1,2-Dihydro-2,5-diphenyl-3H-pyrazol-3-one is used as a reactant in the synthesis of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase.

Upstream product

• 100-63-0 phenylhydrazine 
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• 80030-91-7 (E,Z)-5-Benzylidene-3-benzyl-2,4-dioxo-1,3-thiazolidine 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 537-47-3 4-phenyl-semicarbazide 
• 4369-55-5 3-phenyl-isoxazol-5-ylamine 
• 126230-43-1 8-Chloro-4-phenyl-1,5-dihydro-benzo[b][1,4]diazepin-2-one 
• 80030-93-9 3-Benzyl-2,4-dioxo-5-<α-(2-phenylhydrazino)-benzyl>-tetrahydro-1,3-thiazole 
• 52028-95-2 β-amino-cinnamic acid amide 

Downstream Products

• 96071-05-5 4-(4-diethylamino-2-methyl-phenylimino)-2,5-diphenyl-2,4-dihydro-pyrazol-3-one 
• 24664-63-9 4-(4-ethoxy-anilinomethylene)-2,5-diphenyl-2,4-dihydro-pyrazol-3-one 
• 65699-61-8 4-(4-bromo-anilinomethylene)-2,5-diphenyl-2,4-dihydro-pyrazol-3-one 
• 55299-88-2 4-aminomethylene-2,5-diphenyl-2,4-dihydro-pyrazol-3-one 
• 15900-13-7 (3-oxo-2,5-diphenyl-2,3-dihydro-1H-pyrazol-4-yl)-(5-oxo-1,3-diphenyl-1,5-dihydro-pyrazol-4-ylidene)-methane 
• 118717-23-0 4-(4-diethylamino-phenylimino)-2,5-diphenyl-2,4-dihydro-pyrazol-3-one 
• 60759-61-7 1,3-diphenyl-4-hydroxyimino-5-pyrazolone 
• 77169-05-2 4,4-dibromo-1,3-diphenyl-2-pyrazolin-5-one 
• 30020-86-1 1,3-diphenyl-4-methyl-1H,6H-pyrano<2,3-c>pyrazol-6-one 
• 52744-73-7 4-amino-1-methyl-2,5-diphenylpyrazole-3-one 

Relevant articles and documents

Synthesis, mechanism and efficient modulation of a fluorescence dye by photochromic pyrazolone with energy transfer in the crystalline state

A dual-responsive photochromic compound, 1,3-diphenyl-4-(3-chloro-4-pyridylformyl)-5-hydroxypyrazole 4-phenylsemicarbazone (1) based on a pyrazolone derivative with excellent reversible photochromic reactions in the crystalline state, was successfully synthesized. The new photochromic mechanism of 1 is attributed to isomerization between the enol form and keto form with proton transfer, which was confirmed by IR, XPS, crystal structure data and theoretical calculation. In order to achieve high-contrast fluorescence switch capability, two-component composite materials (TCCM) were prepared by co-aggregating. The emission intensity of fluorophore 9,10-diphenylanthracene (DPA) can be efficiently switched by the fluorescence resonance energy transfer (FRET) between the donor DPA and acceptor coloured 1 in TCCM. The fluorescence modulation ratio is found to be 79%, which is influenced by changing the content of DPA. This novel photoswitchable TCCM may have potential application as photoswitches.

PYRAZOLONE DERIVATIVE HAVING CYCLIC SIDE CHAIN

PROBLEM TO BE SOLVED: To provide a compound that has excellent inhibitory action on ATPase activity of TIP48/TIP49 complex and is therefore useful for the treatment of tumor, or a pharmacologically acceptable salt thereof. SOLUTION: The present invention provides a compound having a structure represented by general formula (I), its pharmacologically acceptable salt, or a pharmaceutical composition comprising the compound (where R1, R2, R3, R4, R5, R6, R7, W, and Z are as defined in the specifications). SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Organotin(IV) derivatives of novel β-diketones: Part V. Synthesis and characterization of di- and triorganotin(IV) derivatives of 4-acyl-5-pyrazolones modified in position 3 of the pyrazole. Crystal structure of (1,3-diphenyl-4-benzoyl-pyrazolon-5-ato)tri

The interaction between R3SnCl, (R3Sn)2O, R2SnO or R2SnCl2 acceptors (R = Me, nBu or Ph) and the two novel β-diketone proligands (LH = 1,3-diphenyl-4-R4(C=O)-pyrazol-5